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The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface
TLDR
It is shown that the conditional deletion of the small Rho-GTPase cdc42 at different stages of neurogenesis in mouse telencephalon results in an immediate increase in basal mitoses, thereby regulating the position of mitoses and cell fate. Expand
The integrin–actin connection, an eternal love affair
TLDR
This review presents several examples of this paradigm and with special emphasis on the ILK–PINCH–parvin complex, which amply demonstrates how structural and signalling functions are linked together. Expand
Cdc42 Regulates Cofilin during the Establishment of Neuronal Polarity
TLDR
It is concluded that Cdc42 is a key regulator of axon specification, and cofilin is a physiological downstream effector of CDC42 in this process, and that cofil in was enriched in the axonal growth cones of wild-type, but not of mutant, neurons. Expand
Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development
TLDR
This work uses tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Expand
Cdc42-Mediated Tubulogenesis Controls Cell Specification
TLDR
Evidence is presented that Cdc42 is essential for tube formation, specifically for initiating microlumen formation and later for maintaining apical cell polarity, and it is shown that CDC42 controls cell specification non-cell-autonomously by providing the correct microenvironment for proper control of cell-fate choices of multipotent progenitors. Expand
Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.
TLDR
Findings establish that beta1-integrin-dependent motility and proliferation of chondrocytes are mandatory events for endochondral bone formation to occur. Expand
Integrins in invasive growth.
TLDR
How integrins affect migration, proliferation, and survival of both transformed and normal cells are described, and how they modulate invasive growth in vivo is discussed. Expand
Brevican-Deficient Mice Display Impaired Hippocampal CA1 Long-Term Potentiation but Show No Obvious Deficits in Learning and Memory
TLDR
The data indicate that brevican is not crucial for brain development but has restricted structural and functional roles, suggesting a complex cause for the LTP defect. Expand
Functional Inactivation of a Fraction of Excitatory Synapses in Mice Deficient for the Active Zone Protein Bassoon
TLDR
It is shown that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses. Expand
FMNL2 Drives Actin-Based Protrusion and Migration Downstream of Cdc42
TLDR
It is established that the FMNL subfamily member FMNL2 is a novel elongation factor of actin filaments that constitutes the first Cdc42 effector promoting cell migration and actin polymerization at the tips of lamellipodia. Expand
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