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Enzymatic basis for the transesterification of cocaine in the presence of ethanol: evidence for the participation of microsomal carboxylesterases.
The enzyme-mediated transesterification of the 2-carboxymethyl ester of cocaine to a 2-carboxyethyl ester in the presence of ethanol has been characterized in mice by using both in vitro and in vivo… Expand
Submitochondrial localization of the NAD+ glycohydrolase. Implications for the role of pyridine nucleotide hydrolysis in mitochondrial calcium fluxes.
- C. Boyer, G. Moore, P. Moldéus
- Medicine, Chemistry
- The Journal of biological chemistry
- 25 February 1993
The submitochondrial location of the NAD+ glycohydrolase (NADase) and its role in mitochondrial ADP-ribosyl transfer reactions were investigated in isolated rat liver mitochondria. The NADase… Expand
Predictive Models of CYP3A4 Heteroactivation: In Vitro-in Vivo Scaling and Pharmacophore Modeling
- Ann-Charlotte Egnell, J. Houston, C. Boyer
- Chemistry, Medicine
- Journal of Pharmacology and Experimental…
- 1 March 2005
Although activation of CYP3A4 is frequently observed in vitro, predictive computational-based models and methods for in vitro-in vivo scaling are scarce. It has been previously shown that in vitro… Expand
Potentiation of cocaine-mediated hepatotoxicity by acute and chronic ethanol.
Cocaine has been associated with hepatotoxicities in man and is a potent hepatotoxin in mice. The theorized toxic metabolite of cocaine is thought to be generated by a multistep pathway mediated… Expand
Evidence for the activation of the signal-responsive phospholipase A2 by exogenous hydrogen peroxide.
- C. Boyer, G. Bannenberg, E. Neve, Å. Ryrfeldt, P. Moldéus
- Chemistry, Medicine
- Biochemical pharmacology
- 7 September 1995
The intracellular events that lead to arachidonic acid release from bovine endothelial cells in culture treated with hydrogen peroxide were characterized. The hydrogen peroxide-stimulated release of… Expand
The metabolism of 3,7-dimethyl-2,6-octadienal (citral) in rat hepatic mitochondrial and cytosolic fractions. Interactions with aldehyde and alcohol dehydrogenases.
Citral (3,7-dimethyl-2,6-octadienal), a flavoring and fragrance agent, is associated with a variety of biochemical and toxicological effects. Reports of the in vivo metabolism of citral suggest that… Expand
Cocaine-induced biochemical changes and cytotoxicity in hepatocytes isolated from both mice and rats.
The mechanism of cocaine-induced cytotoxicity was investigated in hepatocytes isolated from both male C3H mice and male Sprague-Dawley rats. Cocaine was more cytotoxic to mouse hepatocytes than rat… Expand
N-ethyl maleimide stimulates arachidonic acid release through activation of the signal-responsive phospholipase A2 in endothelial cells.
Treatment of bovine endothelial cells with the alkylator N-ethyl maleimide results in arachidonic acid mobilization. N-ethyl maleimide-stimulated arachidonic acid release was dose and time dependent… Expand
Hepatic biochemical changes as a result of acute cocaine administration in the mouse
The biochemical mechanism of cocaine hepatotoxicity is thought to involve enzymatic formation of reactive metabolites. The exact hepatocellular effects of these metabolites have yet to be… Expand
Sex and strain differences in the hepatotoxic response to acute cocaine administration in the mouse.
Cocaine-induced hepatotoxicity was examined in vivo in a dose-responsive manner in C57BL/6Ibg, DBA/2Ibg, C3H/2Ibg, and Balb/cJ mice. Serum glutamic-pyruvic transaminase (SGPT) activities were… Expand