• Publications
  • Influence
A model of airway narrowing in asthma and in chronic obstructive pulmonary disease.
We have examined the effect of airway wall thickening, loss of lung recoil, and airway smooth muscle shortening on the increase in airway resistance using a model of the human tracheobronchial tree.Expand
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Small airways dimensions in asthma and in chronic obstructive pulmonary disease.
The purpose of this study was to compare the dimensions of the peripheral airways in fatal asthma with those from patients with nonfatal asthma, mild COPD, and normal lung function. Lung specimensExpand
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Small airway dimensions in smokers with obstruction to airflow.
The obstruction to airflow that develops in some cigarette smokers is thought to be related to inflammation of small airways. However, the mechanism by which inflammation leads to obstruction has notExpand
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Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers using immunocytochemistry.
Lung tissue from 20 patients undergoing resection for a peripheral carcinoma was studied using monoclonal antibodies to identify inflammatory cell types in the peripheral airways and to determine theExpand
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Oxygen delivery in critically ill patients. Relationship to blood lactate and survival.
Forty-four critically ill patients with or without adult respiratory distress syndrome (ARDS) were studied in an attempt to define critical levels of oxygen delivery. Blood lactate was used as theExpand
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Comparison of gallium-67 scanning, bronchoalveolar lavage, and serum angiotensin-converting enzyme levels in pulmonary sarcoidosis. Predicting response to therapy.
Patients with active pulmonary sarcoidosis underwent bronchoalveolar lavage, gallium scan, and serum angiotensin-converting enzyme (ACE) level determination prior to treatment with corticosteroids.Expand
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The comparative mechanics and morphology of airways in asthma and in chronic obstructive pulmonary disease.
Although airway obstruction characterizes the functional defect in patients who have asthma as well as in patients who have chronic obstructive pulmonary disease (COPD), dif­ ferent mechanisms areExpand
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Effects of hypohydration on lung functions in humans.
We studied lung function tests during euhydration (Days 1 and 2), hypohydration (Days 3 and 4), and rehydration (Days 5, 6, and 7) in 6 normal subjects. Hypohydration was induced by administeringExpand
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Diagnosis, Treatment, and Prevention of Pulmonary Embolism: Report of the WHO/International Society and Federation of Cardiology Task Force
To assess the state of the art of venous thrombosis and pulmonary embolism for the medical and other health-related professions, the World Health Organization (WHO) and the International Society andExpand
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Quantitation of bronchoalveolar lavage with methylene blue.
Bronchoalveolar lavage yields a return that is composed of lung liquid and lavage liquid in variable and unknown proportions. Concentrations of chemicals and cells in lung liquid have been presentedExpand
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