• Publications
  • Influence
The emerging roles of human tissue kallikreins in cancer
TLDR
Human tissue kallikreins, which are encoded by the largest contiguous cluster of protease genes in the human genome, are secreted serine proteases with diverse expression patterns and physiological roles that might represent attractive targets for therapeutic intervention. Expand
Human tissue kallikreins: physiologic roles and applications in cancer.
TLDR
Many kallikreins, in addition to hK3/PSA, have been identified as promising diagnostic and/or prognostic biomarkers for several cancer types, including ovarian, breast, and prostate. Expand
A Potential Role for Multiple Tissue Kallikrein Serine Proteases in Epidermal Desquamation*
TLDR
It is indicated that multiple KLKs may participate in desquamation through cleavage of desmoglein 1 and regulation by LEKTI and these findings may have clinical implications for the treatment of skin disorders in which KLK activity is elevated. Expand
Human tissue kallikreins: the cancer biomarker family.
TLDR
The identification of kallikrein substrates and the development of proteolytic cascade models implicate kallkrein proteins in cancer progression, and the current status of k allikreins as cancer biomarkers is described. Expand
Expression and Functional Characterization of the Cancer-related Serine Protease, Human Tissue Kallikrein 14*
TLDR
KK14 may be implicated in several facets of tumor progression, including growth, invasion, and angiogenesis, as well as in arthritic disease via deterioration of cartilage, which may have clinical implications for the management of cancer and other disorders in which KLK14 activity is elevated. Expand
A survey of alternative transcripts of human tissue kallikrein genes.
TLDR
This review presents a systematic analysis of all currently known kallikrein alternative transcripts and identifies 82 different kallIKrein gene transcript forms, including reference forms. Expand
Enzymatic profiling of human kallikrein 14 using phage-display substrate technology
TLDR
It is shown that hK14 has dual activity, trypsin- and chymotrypsIn-like, with a preference for cleavage after arginine residues, and two of them, laminin α-5 and collagen IV, have been demonstrated to be hydrolyzed efficiently by hK 14. Expand
Defining the extended substrate specificity of kallikrein 1-related peptidases
TLDR
The results indicate that these KLKs share a P1 preference for Arg, but each KLK exhibited distinct P2–P4 specificities, attributable to structural variations in their surface loops, and can be used in the development of selective KLK inhibitors. Expand
Human kallikrein 14: a new potential biomarker for ovarian and breast cancer.
TLDR
Preliminary data indicate that hK14, a recently discovered member of the tissue kallikrein family of secreted serine proteases, is a potential biomarker for breast and ovarian cancers. Expand
Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer.
TLDR
The preliminary data indicate that hK5 is a potential biomarker in patients with ovarian and breast cancer, and a sandwich-type microplate immunoassay (ELISA) was developed using these antibodies, coupled with a time-resolved fluorometric detection technique. Expand
...
1
2
3
4
5
...