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Metabolic Syndrome in Childhood: Association With Birth Weight, Maternal Obesity, and Gestational Diabetes Mellitus
Analysis of insulin resistance at 11 years in a multivariate logistic regression revealed that childhood obesity and the combination of LGA status and maternal GDM were associated with insulin resistance, with odds ratios of 4.3 and 4.4 (95% CI: 1.5–74.4), respectively. Expand
Insulin resistance syndrome in women with prior history of gestational diabetes mellitus.
It is concluded that obesity and GDM in a prior pregnancy are significant risk factors for developing IRS over time and early detection of markers of IRS is vital for possible prevention of type 2 diabetes and cardiovascular adverse events in women. Expand
Severe endocrine and nonendocrine manifestations of the McCune-Albright syndrome associated with activating mutations of stimulatory G protein GS.
It is concluded that the manifestations of MCAS are more extensive than is generally appreciated, and may include hepatobiliary disease, cardiac disease, other nonendocrine abnormalities, and sudden or premature death. Expand
Gestational diabetes: The forerunner for the development of maternal and childhood obesity and metabolic syndrome?
  • B. Vohr, C. Boney
  • Medicine
  • The journal of maternal-fetal & neonatal medicine…
  • 1 January 2008
The current prevalence of obesity in both adults and children and associated disorders of blood pressure and lipid metabolism suggest a perpetuating cycle of increasing obesity, insulin resistance, and abnormal lipid metabolism, which has ominous consequences for future generations. Expand
Rare complications of pediatric diabetic ketoacidosis.
The pathophysiology, reported cases, management, and outcomes of each of these rare complications in children with type 1 diabetes, including hypercoagulability leading to stroke and deep vein thrombosis, rhabdomyolysis, pulmonary and gastrointestinal complications, and long-term memory dysfunction are reviewed. Expand
The critical role of Shc in insulin-like growth factor-I-mediated mitogenesis and differentiation in 3T3-L1 preadipocytes.
It is hypothesized that down-regulation of MAPK via loss of proximal signaling through Shc is an early component in the IGF-I switch from mitogenesis to differentiation in 3T3-L1 preadipocyte differentiation. Expand
Src family tyrosine kinases participate in insulin-like growth factor I mitogenic signaling in 3T3-L1 cells.
The results are the first to demonstrate thatSFKs mediate IGF-I mitogenic signaling in 3T3-L1 cells and add to the growing body of evidence that SFKs play a crucial role in IGF- I action. Expand
Inhibition of insulin‐like growth factor‐I mitogenic action by zinc chelation is associated with a decreased mitogen‐activated protein kinase activation in RAT‐1 fibroblasts
It is shown that zinc chelation by DTPA inhibits [3H]thymidine incorporation stimulated by IGF‐I in Rat‐1 fibroblasts, and this inhibition is potentially caused by decreased MAPK activation by IGF-I. Expand
Human insulin-like growth factor-binding protein-1 (hIGFBP-1) in transgenic mice: characterization and insights into the regulation of IGFBP-1 expression.
The finding that native liver IGFBP-1 mRNA abundance is influenced by transgene expression further supports the concept that both mRNAs share some common mechanisms of regulation. Expand
Modulation of insulin-like growth factor I mitogenic signaling in 3T3-L1 preadipocyte differentiation.
The change in IGF-I signaling via Shc phosphorylation and MAPK activity during 3T3-L1 differentiation indicates that loss of IGF- I mitogenic signaling via the MAPK pathway is part of the differentiation process. Expand