• Publications
  • Influence
Somatic mutations of calreticulin in myeloproliferative neoplasms.
BACKGROUND Approximately 50 to 60% of patients with essential thrombocythemia or primary myelofibrosis carry a mutation in the Janus kinase 2 gene (JAK2), and an additional 5 to 10% have activatingExpand
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Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals
Epigenetic information can be inherited through the mammalian germline and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritanceExpand
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Comprehensive Analysis of DNA Methylation Data with RnBeads
RnBeads is a software tool for large-scale analysis and interpretation of DNA methylation data, providing a user-friendly analysis workflow that yields detailed hypertext reportsExpand
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Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines
The developmental potential of human pluripotent stem cells suggests that they can produce disease-relevant cell types for biomedical research. However, substantial variation has been reported amongExpand
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Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling
Genome-wide mapping of 5-methylcytosine is of broad interest to many fields of biology and medicine. A variety of methods have been developed, and several have recently been advanced to genome-wideExpand
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Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.
To investigate the cell-intrinsic aging mechanisms that erode the function of somatic stem cells during aging, we have conducted a comprehensive integrated genomic analysis of young and aged cells.Expand
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Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
Analysis of DNA methylation patterns relies increasingly on sequencing-based profiling methods. The four most frequently used sequencing-based technologies are the bisulfite-based methods MethylC-seqExpand
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Specification of tissue-resident macrophages during organogenesis
INTRODUCTION Embryonic development and tissue homeostasis depend on cooperation between specialized cell types. Resident macrophages are professional phagocytes that survey their surroundings;Expand
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Analysing and interpreting DNA methylation data
  • C. Bock
  • Biology, Medicine
  • Nature Reviews Genetics
  • 1 October 2012
DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range of biological processes and diseases. The technology is now available for studying DNA methylationExpand
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BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing
TLDR
SUMMARY Manual processing of DNA methylation data from bisulfite sequencing is a tedious and error-prone task. Expand
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