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Clonal success of piliated penicillin nonsusceptible pneumococci
Antibiotic resistance in pneumococci is due to the spread of strains belonging to a limited number of clones. The Spain9V-3 clone of sequence type (ST)156 is one of the most successful clones withExpand
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Pattern of accessory regions and invasive disease potential in Streptococcus pneumoniae.
BACKGROUND The invasive disease potential (IDP) of Streptococcus pneumoniae differs between serotypes, but the reason for this is unknown. METHODS A total of 47 pneumococcal isolates from 13Expand
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The rise and fall of bacterial clones: Streptococcus pneumoniae
Globally spreading bacterial strains belong to clonal types that have the capacity to colonize, spread and cause disease in the community. Recent comparative genomic analyses of well-defined clinicalExpand
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Determination of Accessory Gene Patterns Predicts the Same Relatedness among Strains of Streptococcus pneumoniae as Sequencing of Housekeeping Genes Does and Represents a Novel Approach in Molecular
ABSTRACT Relatedness between isolates of Streptococcus pneumoniae can be determined from sequences of multiple genes belonging to the core genome (multilocus sequence typing [MLST]), but these do notExpand
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The influence of in vitro fitness defects on pneumococcal ability to colonize and to cause invasive disease
BackgroundStreptococcus pneumoniae is a genetically diverse major human pathogen, yet a common colonizer of the nasopharynx. Here we analyzed the influence of defects affecting in vitro growth rate,Expand
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Streptococcus pneumoniae is a human pathogen and a major contributor to morbidity and mortality worldwide. It has been estimated that it is responsible for between 1-2 million deaths annually. TheExpand