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Dengue Virus Type 2 Infections of Aedes aegypti Are Modulated by the Mosquito's RNA Interference Pathway
It is shown that although dengue virus type 2 (DENV2) infection of Ae. Expand
RNA interference acts as a natural antiviral response to O'nyong-nyong virus (Alphavirus; Togaviridae) infection of Anopheles gambiae.
Observations provide direct evidence that RNAi is an antagonist of ONNV replication in A. gambiae, and they suggest that the innate immune response conditions vector competence. Expand
Aedes aegypti uses RNA interference in defense against Sindbis virus infection
BackgroundRNA interference (RNAi) is an important anti-viral defense mechanism. The Aedes aegypti genome encodes RNAi component orthologs, however, most populations of this mosquito are readilyExpand
La Crosse Bunyavirus Nonstructural Protein NSs Serves To Suppress the Type I Interferon System of Mammalian Hosts
It is demonstrated that mosquito cells persistently infected with LACV do not undergo apoptosis and mount a specific RNAi response and indicates that NSs has no function in the insect vector. Expand
Comparison of Dengue Virus Type 2-Specific Small RNAs from RNA Interference-Competent and –Incompetent Mosquito Cells
It is shown that defective expression or function of Dcr2, the key initiator of the RNAi pathway, might explain the comparatively robust growth of arthropod-borne viruses in the C6/36 cell line, which has been used frequently as a surrogate for studying molecular interactions between arboviruses and cells of their mosquito hosts. Expand
Mosquito RNAi is the major innate immune pathway controlling arbovirus infection and transmission.
  • C. Blair
  • Biology, Medicine
  • Future microbiology
  • 31 March 2011
The current knowledge of mosquito antiviral RNAi is reviewed and some of the future directions needed to fill knowledge gaps are charted. Expand
RNA interference, arthropod-borne viruses, and mosquitoes.
It is hypothesize that genetically modified mosquitoes can be generated that transcribe a flavivirus-specific dsRNA, triggering the RNAi response soon after ingestion of a blood meal, which could induce theRNAi pathway in the midgut prior to establishment of virus infection and profoundly change vector competence. Expand
C6/36 Aedes albopictus Cells Have a Dysfunctional Antiviral RNA Interference Response
Results suggest that C6/36 cells lack a functional antiviral RNAi response, analogous to the type-I interferon deficiency described in Vero (African green monkey kidney) cells, and suggest that it may fail to accurately model mosquito-arbovirus interactions at the molecular level. Expand
Insect-specific flaviviruses from Culex mosquitoes in Colorado, with evidence of vertical transmission.
Mosquitoes were collected in Colorado during 2006 and 2007 to examine spatial and seasonal patterns of risk for exposure to Culex vectors and West Nile virus, which led to the detection and subsequent isolation of two insect-specific flaviviruses: CuleX flavivirus (CxFV), which was first described from Japan, and a novel insect flaviv virus, designated Calbertado virus (CLBOV, which has also been detected in California and Canada. Expand