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Safety and antitumor activity of recombinant soluble Apo2 ligand.
TLDR
Apo2L may have potent anticancer activity without significant toxicity toward normal tissues, and cooperated synergistically with the chemotherapeutic drugs 5-fluorouracil or CPT-11, causing substantial tumor regression or complete tumor ablation.
Lid Wiper Epitheliopathy and Dry Eye Symptoms
TLDR
Lid wiper epitheliopathy, diagnosed by staining with fluorescein and rose bengal dyes, is a frequent finding when symptoms of dry eye are experienced in the absence of routine clinical dry eye findings.
A New System, the LipiFlow, for the Treatment of Meibomian Gland Dysfunction
TLDR
The LipiFlow System was significantly more effective than the iHeat Warm Compress for adults with meibomian gland dysfunction and dry eye symptoms and these results support its safety and effectiveness in the treatment of MGD and Dry eye symptoms.
Nonobvious Obstructive Meibomian Gland Dysfunction
TLDR
This review presents the rationale and supporting data for a recent paradigm shift in the understanding of meibomian gland dysfunction, and presents the specific treatment of NOMGD, emphasizing that the success of treatment of all forms of obstructive MGD is dependent on the relief of the obstruction.
Psychometric Properties and Validation of the Standard Patient Evaluation of Eye Dryness Questionnaire
TLDR
The SPEED questionnaire was shown to be a repeatable and valid instrument for measurement of dry eye symptoms and correlated significantly with ocular surface staining and clinical measures of meibomian gland function.
The Effect of Two Novel Lubricant Eye Drops on Tear Film Lipid Layer Thickness in Subjects With Dry Eye Symptoms
TLDR
In subjects with symptoms indicative of dry eye states and LLT ≤75 nm, one eye drop of Soothe more than doubled LLT, a 107% mean increase, whereas Systane increased LLT by 16%.
Prevalence of Lid Wiper Epitheliopathy in Subjects With Dry Eye Signs and Symptoms
TLDR
The prevalence of lid wiper epitheliopathy (LWE) in patients diagnosed with dry eye disease was six times greater for the DED group than for the control group and the prevalence of LWE Grade 2 or greater was 16 times great for theDED group more than forThe control group.
Inner Eyelid Surface Temperature as a Function of Warm Compress Methodology
TLDR
To optimize WC efficiency, patients should reheat the WC frequently and have a replacement heated WC on hand for exchange, and perform the activity for at least 4 min in order to achieve an inner lower eyelid temperature ≥ 40°C.
Meibomian Gland Diagnostic Expressibility: Correlation With Dry Eye Symptoms and Gland Location
TLDR
This is the first report to document a correlation between the number of meibomian glands yielding liquid secretion in the lower eyelid and dry eye symptoms, and theNumber of MGYLS varies significantly across the higher eyelid, with the highest number of MgyLS in the nasal third and the lowest number in the temporal third.
The Relationship Between Dry Eye Symptoms and Lipid Layer Thickness
TLDR
Investigation of relationship between dry eye symptoms and lipid layer thickness (LLT) in patients presenting for routine eye examination and the practicality of interferometry in a clinical practice indicates that LLT seems to correlate better to symptoms, especially severe symptoms, than other reported correlations with objective clinical tests for dry eye disease.
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