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Epidermal growth factor receptor (EGFR) signaling in cancer.
Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo.
- H. Adkins, C. Bianco, M. Sanicola
- Biology, ChemistryThe Journal of clinical investigation
- 15 August 2003
It is reported, for the first time to the authors' knowledge, that Cripto can directly bind to another TGF-beta ligand, Activin B, and thatCripto overexpression blocks ActivinB growth inhibition of breast cancer cells, suggesting a novel mechanism for antagonizing Activin signaling that could promote tumorigenesis by deregulating growth homeostasis.
Cripto-1 Activates Nodal- and ALK4-Dependent and -Independent Signaling Pathways in Mammary Epithelial Cells
CR-1 binds to cell surface ALK4 expressed on mammalian epithelial cells in fluorescence-activated cell sorter analysis, as well as by coimmunoprecipitation, suggesting that CR-1 may modulate different signaling pathways to mediate its different functional roles.
Cripto-1: a multifunctional modulator during embryogenesis and oncogenesis
The role of Cripto-1 during embryogenesis, cell migration, invasion and angiogenesis and how these activities may relate to cellular transformation and tumorigenesis are reviewed.
Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment.
- N. Normanno, C. Bianco, A. De Luca, M. Maiello, D. Salomon
- BiologyEndocrine-related cancer
- 1 March 2003
The mechanisms of action of these compounds, as well as the potential therapeutic strategies to improve their efficacy are discussed in this review with particular regard to the combinations of anti-ErbB agents with cytotoxic drugs, or combinations of different ErbB-targeting agents.
Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV‐Cripto‐1 transgenic mice
The expression of molecular markers and signaling molecules characteristic of EMT were assessed in mammary gland hyperplasias and tumors from mice expressing the human CR‐1 transgene by the MMTV promoter (MMTV‐CR‐1) and in mouse mammary epithelial cell line HC‐11 overexpressing CR‐2.
Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.
The role of EGF-related peptides in tumor growth.
- N. Normanno, C. Bianco, A. De Luca, D. Salomon
- BiologyFrontiers in bioscience : a journal and virtual…
- 1 May 2001
Data strongly suggest that the EGF-like peptides are involved in the pathogenesis of human carcinomas, and that they might represent suitable targets for novel therapeutic approaches.
Requirement of Glycosylphosphatidylinositol Anchor of Cripto-1 for trans Activity as a Nodal Co-receptor*
GPI attachment of CR-1 is required for the paracrine activity as a Nodal co-receptor in trans as well as in cis, and COOH-terminal-truncated soluble forms ofCR-1 are generated based on the attachment site for the GPI moiety.
A Nodal- and ALK4-independent signaling pathway activated by Cripto-1 through Glypican-1 and c-Src.
It is demonstrated that CR-1 specifically binds to Glypican-1, a membrane-associated heparan sulfate proteoglycan, and activates the tyrosine kinase c-Src, triggering the mitogen-activated protein kinase and Akt signaling pathways.