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- Publications
- Influence
Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo.
- Heather B. Adkins, C. Bianco, +15 authors M. Sanicola
- Biology, Medicine
- The Journal of clinical investigation
- 15 August 2003
Cripto, a cell surface-associated protein belonging to the EGF-CFC family of growth factor-like molecules, is overexpressed in many human solid tumors, including 70-80% of breast and colon tumors,… Expand
Cripto-1 Activates Nodal- and ALK4-Dependent and -Independent Signaling Pathways in Mammary Epithelial Cells
- C. Bianco, Heather B. Adkins, +10 authors D. Salomon
- Biology, Medicine
- Molecular and Cellular Biology
- 15 April 2002
ABSTRACT Cripto-1 (CR-1), an epidermal growth factor-CFC (EGF-CFC) family member, has a demonstrated role in embryogenesis and mammary gland development and is overexpressed in several human tumors.… Expand
Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment.
- N. Normanno, C. Bianco, A. de Luca, M. Maiello, D. Salomon
- Biology, Medicine
- Endocrine-related cancer
- 1 March 2003
The ErbB receptors and their cognate ligands that belong to the epidermal growth factor (EGF) family of peptides are involved in the pathogenesis of different types of carcinomas. In fact, the ErbB… Expand
The role of EGF-related peptides in tumor growth.
- N. Normanno, C. Bianco, A. de Luca, D. Salomon
- Biology, Medicine
- Frontiers in bioscience : a journal and virtual…
- 1 May 2001
The epidermal growth factor (EGF) family of peptides encodes several proteins that can function as growth factors. The EGF-like peptides, with the exception of proteins of the EGF-CFC subfamily, bind… Expand
Cripto-1: a multifunctional modulator during embryogenesis and oncogenesis
- L. Strizzi, C. Bianco, N. Normanno, D. Salomon
- Biology, Medicine
- Oncogene
- 29 August 2005
It is increasingly evident that genes known to perform critical roles during early embryogenesis, particularly during stem cell renewal, pluripotentiality and survival, are also expressed during the… Expand
Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV‐Cripto‐1 transgenic mice
- L. Strizzi, C. Bianco, +8 authors D. Salomon
- Biology, Medicine
- Journal of cellular physiology
- 1 November 2004
Epithelial‐mesenchymal transition (EMT) facilitates migration and invasion of epithelial tumor cells. Cripto‐1 (CR‐1), a member of the epidermal growth factor‐CFC protein family increases migration… Expand
Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer.
- M. C. Rangel, H. Karasawa, N. Castro, Tadahiro Nagaoka, D. Salomon, C. Bianco
- Medicine, Biology
- The American journal of pathology
- 1 June 2012
Epithelial-to-mesenchymal transition (EMT) is a critical multistep process that converts epithelial cells to more motile and invasive mesenchymal cells, contributing to body patterning and… Expand
The ErbB receptors and their ligands in cancer: an overview.
- N. Normanno, C. Bianco, +5 authors D. Salomon
- Biology, Medicine
- Current drug targets
- 1 May 2005
This review article provides an overview on the most recent advances on the role of ErbB receptors and growth factors of the epidermal growth factor (EGF)-family of peptides in cancer pathogenesis… Expand
Requirement of Glycosylphosphatidylinositol Anchor of Cripto-1 for trans Activity as a Nodal Co-receptor*
- K. Watanabe, S. Hamada, +6 authors D. Salomon
- Biology, Medicine
- Journal of Biological Chemistry
- 7 December 2007
Cripto-1 (CR-1) has an indispensable role as a Nodal co-receptor for patterning of body axis in embryonic development. CR-1 is reported to have a paracrine activity as a Nodal co-receptor, although… Expand
A Nodal- and ALK4-independent signaling pathway activated by Cripto-1 through Glypican-1 and c-Src.
- C. Bianco, L. Strizzi, +10 authors D. Salomon
- Biology, Medicine
- Cancer research
- 15 March 2003
Human Cripto-1 (CR-1) is a member of the epidermal growth factor-Cripto FRL1 Cryptic family that has been shown to function as a coreceptor with the type I Activin serine-threonine kinase receptor… Expand