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VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
- H. Gerhardt, M. Golding, +8 authors C. Betsholtz
- Biology, Medicine
- The Journal of cell biology
- 23 June 2003
Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. It controls several processes in endothelial cells, such as proliferation, survival, and… Expand
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.
Pericytes, the mural cells of blood microvessels, have recently come into focus as regulators of vascular morphogenesis and function during development, cardiovascular homeostasis, and disease.… Expand
Role of platelet-derived growth factors in physiology and medicine.
Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and… Expand
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Cellular diversity in the brain revealed The mammalian brain has an extraordinarily large number of cells. Although there are quite a few different cell types, many cells in any one category tend to… Expand
Pericytes regulate the blood–brain barrier
The blood–brain barrier (BBB) consists of specific physical barriers, enzymes and transporters, which together maintain the necessary extracellular environment of the central nervous system (CNS).… Expand
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
Lymphatic vessels are essential for immune surveillance, tissue fluid homeostasis and fat absorption. Defects in lymphatic vessel formation or function cause lymphedema. Here we show that the… Expand
Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.
Platelet-derived growth factor (PDGF)-B-deficient mouse embryos were found to lack microvascular pericytes, which normally form part of the capillary wall, and they developed numerous capillary… Expand
Interactions between endothelial cells and mural cells (pericytes and vascular smooth muscle cells) in the blood vessel wall have recently come into focus as central processes in the regulation of… Expand
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
In sprouting angiogenesis, specialized endothelial tip cells lead the outgrowth of blood-vessel sprouts towards gradients of vascular endothelial growth factor (VEGF)-A. VEGF-A is also essential for… Expand
Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse.
- M. Hellström, M. Kalén, P. Lindahl, A. Abramsson, C. Betsholtz
- Biology, Medicine
- 15 July 1999
Development of a vascular system involves the assembly of two principal cell types - endothelial cells and vascular smooth muscle cells/pericytes (vSMC/PC) - into many different types of blood… Expand