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TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression.
Frequent gene amplification of the receptor-activated calcium-dependent chloride channel TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its involvement in humanExpand
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SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia
Human bronchial epithelial (HBE) cells exhibit constitutive anion secretion that is absent in cells from cystic fibrosis (CF) patients. The identity of this conductance is unknown, but SLC26A9, aExpand
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The role of regulated CFTR trafficking in epithelial secretion.
The focus of this review is the regulated trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) in distal compartments of the protein secretory pathway and the question of howExpand
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Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia
  • F. Sun, Z. Mi, +8 authors R. Frizzell
  • Medicine, Biology
  • FASEB journal : official publication of the…
  • 1 September 2008
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF). The most common mutation, ΔF508, omits the phenylalanine residue at position 508 in theExpand
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The CFTR trafficking mutation F508del inhibits the constitutive activity of SLC26A9.
Several members of the SLC26A family of anion transporters associate with CFTR, forming complexes in which CFTR and SLC26A functions are reciprocally regulated. These associations are thought to beExpand
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To “Grow” or “Go”: TMEM16A Expression as a Switch between Tumor Growth and Metastasis in SCCHN
Purpose: Tumor metastasis is the leading cause of death in patients with cancer. However, the mechanisms that underlie metastatic progression remain unclear. We examined TMEM16A (ANO1) expression asExpand
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Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis
cAMP/PKA stimulation elicited posttranslational increases in CFTR expression and the interaction of specific 14-3-3 proteins with phosphorylated sites within the R region. This improved theExpand
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Niflumic acid inhibits ATP-stimulated exocytosis in a mucin-secreting epithelial cell line.
ATP is an efficacious secretagogue for mucin and chloride in the epithelial cell line HT29-Cl.16E. Mucin release has been measured as [3H]glucosamine-labeled product in extracellular medium and asExpand
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PKA Regulates Vacuolar H+-ATPase Localization and Activity via Direct Phosphorylation of the A Subunit in Kidney Cells*
The vacuolar H+-ATPase (V-ATPase) is a major contributor to luminal acidification in epithelia of Wolffian duct origin. In both kidney-intercalated cells and epididymal clear cells, cAMP inducesExpand
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Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cells.
The cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP/PKA-activated anion channel, undergoes efficient apical recycling in polarized epithelia. The regulatory mechanisms underlyingExpand
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