• Publications
  • Influence
Essentials of Glycobiology
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans
A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems.
TLDR
A strain-promoted [3 + 2] cycloaddition between cyclooctynes and azides that proceeds under physiological conditions without the need for a catalyst was demonstrated by selective modification of biomolecules in vitro and on living cells, with no apparent toxicity.
Bioorthogonal chemistry: fishing for selectivity in a sea of functionality.
TLDR
The bioorthogonal chemical reactions developed to date are described and how they can be used to study biomolecules.
Methods and Applications
TLDR
The aim of the research presented in this thesis is to create new methods for design for manufacturing, by using several approaches of KE, and find the beneficial and less beneficial aspects of these methods in comparison to each other and earlier research.
Copper-free click chemistry for dynamic in vivo imaging
TLDR
A Cu-free variant of click chemistry that can label biomolecules rapidly and selectively in living systems, overcoming the intrinsic toxicity of the canonical Cu-catalyzed reaction is reported.
Symbol Nomenclature for Graphical Representations of Glycans.
Author(s): Varki, Ajit; Cummings, Richard D; Aebi, Markus; Packer, Nicole H; Seeberger, Peter H; Esko, Jeffrey D; Stanley, Pamela; Hart, Gerald; Darvill, Alan; Kinoshita, Taroh; Prestegard, James J;
Cell surface engineering by a modified Staudinger reaction.
TLDR
A chemical transformation that permits the selective formation of covalent adducts among richly functionalized biopolymers within a cellular context is presented and should permit its execution within a cell's interior, offering new possibilities for probing intracellular interactions.
The Glycosylphosphatidylinositol Anchor: A Complex Membrane-Anchoring Structure for Proteins†
TLDR
The structural diversity of the GPI anchor and its putative cellular functions, including involvement in lipid raft partitioning, signal transduction, targeting to the apical membrane, and prion disease pathogenesis are discussed.
Glycans in cancer and inflammation — potential for therapeutics and diagnostics
TLDR
This review highlights changes in glycosylation associated with cancer and chronic inflammation and new therapeutic and diagnostic strategies that are based on the underlying glycobiology.
MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence
TLDR
It is shown that MmpL8, a member of a large family of predicted lipid transporters in M. tuberculosis, is required for SL-1 production and that mMPL8 mutants are attenuated for growth in a mouse model of tuberculosis.
...
...