C. Berthou

Publications369
h-index48
Citations10,635
Highly Influential Citations387
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A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia.
TLDR
TEL-induced oligomerization of TEL-JAK2 resulted in the constitutive activation of its tyrosine kinase activity and conferred cytokine-independent proliferation to the interleukin-3-dependent Ba/F3 hematopoietic cell line.
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Should adolescents with acute lymphoblastic leukemia be treated as old children or young adults? Comparison of the French FRALLE-93 and LALA-94 trials.
TLDR
The findings of this study indicate that adolescents should be included in intensive pediatric protocols and that new trials should be designed, inspired by pediatric protocols, for the treatment of young adults with ALL.
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Maintenance therapy with thalidomide improves survival in patients with multiple myeloma.
TLDR
Thalidomide is an effective maintenance therapy in patients with multiple myeloma and maintenance treatment with pamidronate does not decrease the incidence of bone events.
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Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia.
TLDR
As compared with other treatments, the addition of peginterferon alfa-2a to imatinib therapy resulted in significantly higher rates of molecular response in patients with chronic-phase CML.
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Infectious diseases in the first year of life, perinatal characteristics and childhood acute leukaemia
TLDR
The study supports the hypothesis that early common infections may play a protective role in the aetiology of childhood leukaemia, although this effect was not more marked for common ALL.
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Bortezomib plus dexamethasone versus reduced-dose bortezomib, thalidomide plus dexamethasone as induction treatment before autologous stem cell transplantation in newly diagnosed multiple myeloma.
The Intergroupe Francophone du Myelome conducted a randomized trial to compare bortezomib-dexamethasone (VD) as induction before high-dose therapy (HDT) and autologous stem cell transplantation…
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Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de…
TLDR
In patients with high-risk de novo MM, the combination of ASCT followed by dose-reduced allogeneic transplantation was not superior to tandem dose-intensified, melphalan-based ASCT.
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Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia.
TLDR
It is shown that the p110delta isoform of PI3K is consistently expressed at a high level in blast cells from AML, in contrast to the other class I isoforms, the expression of which was very variable among patients.
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High-dose chemotherapy with autologous stem cell transplantation as first-line therapy for primary CNS lymphoma in patients younger than 60 years: a multicenter phase II study of the GOELAMS group
TLDR
This treatment approach appears feasible in newly diagnosed PCNSL with encouraging results and no evidence of late treatment-related toxicity was observed.
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Occupational exposure to pesticides and lymphoid neoplasms among men: results of a French case-control study
TLDR
The hypothesis that occupational pesticide exposures may be involved in HL, MM and HCL and do not rule out a role in NHL is supported and the findings were consistent with those of previous studies.
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