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Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus
The generation of T cells depends on the migration of hematopoietic progenitor cells to the thymus throughout life. The identity of the thymus-settling progenitor cells has been a matter ofExpand
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Single-Cell Gene Expression Analyses Reveal Heterogeneous Responsiveness of Fetal Innate Lymphoid Progenitors to Notch Signaling.
T and innate lymphoid cells (ILCs) share some aspects of their developmental programs. However, although Notch signaling is strictly required for T cell development, it is dispensable for fetal ILCExpand
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Reconstructing human pancreatic differentiation by mapping specific cell populations during development
Information remains scarce on human development compared to animal models. Here, we reconstructed human fetal pancreatic differentiation using cell surface markers. We demonstrate that at 7weeks ofExpand
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Estrogen-mediated downregulation of AIRE influences sexual dimorphism in autoimmune diseases.
Autoimmune diseases affect 5% to 8% of the population, and females are more susceptible to these diseases than males. Here, we analyzed human thymic transcriptome and revealed sex-associatedExpand
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Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling
ABSTRACT To decipher the populations of cells present in the human fetal pancreas and their lineage relationships, we developed strategies to isolate pancreatic progenitors, endocrine progenitors andExpand
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Molecular and Functional Characterization of Lymphoid Progenitor Subsets Reveals a Bipartite Architecture of Human Lymphopoiesis
&NA; The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid progenitors. Here, using a modeling approachExpand
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Critical Role of TCR Specificity in the Development of Vγ1Vδ6.3+ Innate NKTγδ Cells
A large fraction of innate NKTγδ T cells uses TCRs composed of a semi-invariant Vδ6.3/6.4-Dδ2-Jδ1 chain together with more diverse Vγ1-Jγ4 chains. To address the role of γδTCR specificity in theirExpand
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Asynchronous lineage priming determines commitment to T cell and B cell lineages in fetal liver
The molecular events that initiate lymphoid-lineage specification remain unidentified because the stages of differentiation during which lineage commitment occurs are difficult to characterize. WeExpand
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Inhibitors of DNA Binding Proteins Restrict T Cell Potential by Repressing Notch1 Expression in Flt3-Negative Common Lymphoid Progenitors
Lineage commitment is regulated during hematopoiesis, with stepwise loss of differentiation potential ultimately resulting in lineage commitment. In this study we describe a novel population of B/NKExpand
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Mitochondrial Protein UCP2 Controls Pancreas Development
The mitochondrial carrier uncoupling protein (UCP) 2 belongs to the family of the UCPs. Despite its name, it is now accepted that UCP2 is rather a metabolite transporter than a UCP. UCP2 can regulateExpand
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