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Genetic studies of body mass index yield new insights for obesity biology
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
Defining the role of common variation in the genomic and biological architecture of adult human height
The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid.
New genetic loci link adipose and insulin biology to body fat distribution
A genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation
Cancer risk in patients with diabetes mellitus
Cancer incidence was ascertained in a population-based cohort of 51,008 patients in Uppsala, Sweden, who were given a discharge diagnosis of diabetes mellitus during 1965–83. Complete follow-up…
Excess risk of primary liver cancer in patients with diabetes mellitus.
It is suggested that patients with diabetes are at increased risk of developing primary liver cancer and perhaps cancers of the biliary tract.
A Population-Based Study of the Prevalence of Diabetes and Impaired Glucose Tolerance in Adults in Northern Sudan
The results showed a high prevalence of diabetes in the adult population of Sudan, with a wide difference among the different areas, and the high ratio of newly discovered to previously known diabetic cases may reflect poor public awareness and medical services.
A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension.
Hydchlorothiazide for the treatment of essential hypertension has adverse effects on glucose and lipid metabolism and it is possible, but not proved, that these changes may contribute to the risk for diabetes mellitus and coronary heart disease.
Enhanced early insulin response to glucose in relation to insulin resistance in women with polycystic ovary syndrome and normal glucose tolerance.
- J. Holte, T. Bergh, C. Berne, L. Berglund, H. Lithell
- Medicine, BiologyThe Journal of clinical endocrinology and…
- 1 May 1994
It is concluded that the early insulin response to glucose was increased in women with PCOS, not accounted for by insulin resistance, closely associated to the increased androgenicity, and present also at low-normal BMI.
Restored insulin sensitivity but persistently increased early insulin secretion after weight loss in obese women with polycystic ovary syndrome.
- J. Holte, T. Bergh, C. Berne, L. Wide, H. Lithell
- MedicineThe Journal of clinical endocrinology and…
- 1 September 1995
Insulin resistance in obese women with PCOS was reduced by weight loss to similar levels as BMI-matched control subjects, suggesting that insulin resistance in PCOS is not a feature of PCOS per se.