• Publications
  • Influence
Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons
  • C. Benson, J. Xie, +4 authors P. Snyder
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 19 February 2002
Acidic extracellular solution activates transient H+-gated currents in dorsal root ganglion (DRG) neurons. The biophysical properties of three degenerin/epithelial sodium (DEG/ENaC) channel subunitsExpand
Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons.
Cardiac afferents are sensory neurons that mediate angina, pain that occurs when the heart receives insufficient blood supply for its metabolic demand (ischemia). These neurons display enormousExpand
The mammalian sodium channel BNC1 is required for normal touch sensation
Of the vertebrate senses, touch is the least understood at the molecular level. The ion channels that form the core of the mechanosensory complex and confer touch sensitivity remain unknown. However,Expand
Acid-evoked currents in cardiac sensory neurons: A possible mediator of myocardial ischemic sensation.
Sensory neurons that innervate the heart sense ischemia and mediate angina. To use patch-clamp methods to study ion channels on these cells, we fluorescently labeled cardiac sensory neurons (CSNs) inExpand
Neuropeptide FF and FMRFamide Potentiate Acid-Evoked Currents from Sensory Neurons and Proton-Gated DEG/ENaC Channels
Acidosis is associated with inflammation and ischemia and activates cation channels in sensory neurons. Inflammation also induces expression of FMRFamidelike neuropeptides, which modulate pain. WeExpand
Stomatin Modulates Gating of Acid-sensing Ion Channels*
Acid-sensing ion channels (ASICs) are H+-gated members of the degenerin/epithelial Na+ channel (DEG/ENaC) family in vertebrate neurons. Several ASICs are expressed in sensory neurons, where they playExpand
DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature
Several DEG/ENaC cation channel subunits are expressed in the tongue and in cutaneous sensory neurons, where they are postulated to function as receptors for salt and sour taste and for touch.Expand
The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation
Arterial baroreceptors provide a neural sensory input that reflexly regulates the autonomic drive of circulation. Our goal was to test the hypothesis that a member of the acid-sensing ion channelExpand
Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons
Cardiac afferents are sensory neurons that mediate angina, pain that occurs when the heart receives insufficient blood supply for its metabolic demand (ischemia). These neurons display enormousExpand
ASIC3 in muscle mediates mechanical, but not heat, hyperalgesia associated with muscle inflammation
Abstract Peripheral initiators of muscle pain are virtually unknown, but likely key to development of chronic pain after muscle insult. The current study tested the hypothesis that ASIC3 in muscle isExpand
...
1
2
3
4
5
...