Homozygous transcription factor 3 gene (TCF3) mutation is associated with severe hypogammaglobulinemia and B-cell acute lymphoblastic leukemia.
- M. Ben-ali, Jing Yang, M. Barbouche
- MedicineJournal of Allergy and Clinical Immunology
- 1 October 2017
High level expression of recombinant Mycobacterium tuberculosis culture filtrate protein CFP32 in Pichia pastoris
- C. Benabdesselem, M. Barbouche, M. Jarboui, K. Dellagi, J. Ho, D. M. Fathallah
- BiologyMolecular Biotechnology
- 2007
These data are the first to show that P. pastoris is a suitable host for high-yield production of good quality mycobacterium antigens, and especially culture filtrate proteins that have vaccine and diagnostic potential.
Enhanced Patient Serum Immunoreactivity to Recombinant Mycobacterium tuberculosis CFP32 Produced in the Yeast Pichia pastoris Compared to Escherichia coli and Its Potential for Serodiagnosis of…
- C. Benabdesselem, D. Fathallah, R. Barbouche
- Biology, MedicineJournal of Clinical Microbiology
- 1 September 2006
The trans-production of rCFP32 in P. pastoris significantly improved the serologic detection of CFP32-specific antibodies in patient sera, thereby offering a new, possibly better, modality for producing antigens of diagnostic potential for use in the development of immunoassays for both TB and other infectious diseases.
Implicating bites from a leishmaniasis sand fly vector in the loss of tolerance in pemphigus
- S. Marzouki, I. Zaraa, M. B. Ahmed
- BiologyJCI Insight
- 27 October 2020
Evidence is provided that environmental factors, such as the exposure to P. papatasi bites, can trigger the development of autoimmune antibodies, which might underlie the triggering of anti-Dsg antibodies in patients exposed to sand fly bites.