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Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
TLDR
It is shown that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants, suggesting that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neuroGenesis in the hippocampus.
Antidepressants recruit new neurons to improve stress response regulation
TLDR
It is demonstrated that unpredictable chronic mild stress in mice not only reduces hippocampal neurogenesis, but also dampens the relationship between hippocampus and the main stress hormone system, the hypothalamo-pituitary-adrenal (HPA) axis.
The neurobiology of depression and antidepressant action
Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice
TLDR
The finding of differential strain distributions both with and without diazepam treatment in the light/dark and the elevated plus-maze tests, indicates that not all strains of mice are suitable for investigating the effects of GABA/BZ receptor ligands.
Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues
TLDR
The γ2+/– mice represent a model of anxiety characterized by harm avoidance behavior and an explicit memory bias for threat cues, resulting in heightened sensitivity to negative associations.
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