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Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
TLDR
Substantial insight is provided into the intricate mechanisms of bacterial regulation of the cross-talk between the host and gut microbiota and provides a rationale for the development of a treatment that uses this human mucus colonizer for the prevention or treatment of obesity and its associated metabolic disorders. Expand
Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model
TLDR
Simulating the mucosal gut microbiota represents a breakthrough in modeling and mechanistically studying the human intestinal microbiome in health and disease and may enhance butyrate bioavailability, which could be useful in treating diseases, such as inflammatory bowel disease. Expand
A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
TLDR
It is shown that A. muciniphila retains its efficacy when grown on a synthetic medium compatible with human administration and enhanced its capacity to reduce fat mass development, insulin resistance and dyslipidemia in mice, and Amuc_1100, a specific protein isolated from the outer membrane of A. Sydneyi, interacts with Toll-like receptor 2, is stable at temperatures used for pasteurization and partly recapitulates the beneficial effects of the bacterium. Expand
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota
TLDR
The infant microbiota, the mechanisms that drive its establishment and composition, and how microbial consortia may be molded by natural or artificial interventions are described and the relevance of key microbial players of the infant gut microbiota, in particular bifidobacteria, with respect to their role in health and disease are discussed. Expand
The function of our microbiota: who is out there and what do they do?
TLDR
This review will focus on the current understanding of the functionality of the human intestinal microbiota based on all available metagenome, metatranscriptome, and metaproteome results. Expand
Akkermansia muciniphila and its role in regulating host functions.
TLDR
The aims of this review are to summarize the existing data on the intestinal distribution of A. muciniphila, to provide insight into its ecology and its role in founding microbial networks at the mucosal interface, as well as to discuss recent research on itsrole in regulating host functions that are disturbed in various diseases. Expand
Microbes inside—from diversity to function: the case of Akkermansia
TLDR
The integration of omics- and culture-based approaches with the complexity of the human intestinal microbiota in mind and the mucus-degrading bacteria Akkermansia spp. Expand
The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia
TLDR
It is found that the gut microbiota protects the host during pneumococcal pneumonia, as reflected by increased bacterial dissemination, inflammation, organ damage and mortality in microbiota-depleted mice compared with controls. Expand
Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids
TLDR
The aim of this study was to characterize effects of the microbiota on host epithelium using a novel ex vivo model based on mouse ileal organoids, and demonstrated that organoids provide a powerful tool for host-microbe interaction studies. Expand
Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon
TLDR
The gut microbiota is required for heme-induced epithelial hyperproliferation and hyperplasia because of the capacity to reduce mucus barrier function, and trisulfides can serve as a novel marker of colonic mucolysis and thus as a proxy for mucus Barrier integrity. Expand
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