• Publications
  • Influence
Antitrypanosomal compounds from the essential oil and extracts of Keetia leucantha leaves with inhibitor activity on Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase.
TLDR
Several of its constituents and three triterpenic acids present in the dichloromethane leaves extract showed a higher antitrypanosomal activity on bloodstream forms of Tbb as compared to procyclic forms, namely geranyl acetone, phytol, α-ion one, β-ionone, ursolic acid, oleanolic acid and betulinic acid.
An ecological approach to discover new bioactive extracts and products: the case of extremophile plants
TLDR
Eight extremophile plants from Tunisia were screened to find natural products with benefits in human health that can be applied in medicine and cosmetics.
In Vitro Anti-Leishmanial Activity of Essential Oils Extracted from Vietnamese Plants
TLDR
The results indicated that EOs extracted from Cinnamomum cassia, Zingiber zerumbet, Elsholtzia ciliata and Amomum aromaticum, possessed a moderate anti-leishmanial activity, and the most promising EO was extracted from Ocimum gratissimum, displaying an IC50 of 4.85 ± 1.65 nL/mL and SI > 10.
In vitro antileishmanial and cytotoxicity activities of essential oils from Haplophyllum tuberculatum A. Juss leaves, stems and aerial parts
TLDR
The findings of the present study demonstrated that H. tuberculatum might not be considered as a natural source for production of new anti-leishmanial agents without further analyzing its eventual in vivo toxicity as well as that of major pure compounds.
Identification of antiplasmodial triterpenes from Keetia species using NMR-based metabolic profiling
TLDR
NMR-based metabolomics combined with supervised multivariate data analysis is a powerful strategy for the identification of bioactive metabolites in plant extracts and combination of statistical total correlation spectroscopy with 2D NMR allowed a detailed analysis of different triterpenes.
Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei
TLDR
The antimicrobial potential of phenolic compounds against MRSA clinical isolates, T. brucei and L. mexicana, and their cytotoxic activity was assessed both on cancer and non-cancer human cell lines.
Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia
TLDR
The partitions of the leaves of C. scabrum were analyzed for their antiproliferative activity on the same cell lines and the antimicrobial potential of this plant was also evaluated against 36 microorganisms.
In vivo anti-malarial activity and toxicity studies of triterpenic esters isolated form Keetia leucantha and crude extracts
TLDR
Its activity can be explained by the presence of triterpenic acids and esters which in vivo activity and safety were demonstrated for the first time and brought out new information on the safety of K. leucantha use and on the identification of anti-malarial compounds from its dichloromethane extract.
In vivo Antimalarial and Antitrypanosomal Activity of Strychnogucine B, a Bisindole Alkaloid from Strychnos icaja.
TLDR
Strychnogucine B is a bisindole alkaloid previously isolated from Strychnos icaja that possesses promising in vitro antiplasmodial properties and shows moderate in vitro antitrypanosomal activity but no in vivo activity in an acute Trypanosoma brucei model.
Antiprotozoal activities of Triterpenic Acids and Ester Derivatives Isolated from the Leaves of Vitellaria paradoxa.
TLDR
One isolated triterpenic ester mixture in equilibrium showed an attractive promising antitrypanosomal activity with low cytotoxicity compared to the corresponding acid, and further bioavailability and PK studies are needed along with mode of action investigations to further assess the potential of this molecule.
...
1
2
3
...