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Biosynthetic and biomimetic electrocyclizations.
Pericyclic reactions have long been considered a biosynthetic rarity. In contrast to their prominence in the laboratory, they seemed to play only minor roles in Nature. Over the past decades,Expand
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Chirality in diarylether heptanoids: synthesis of myricatomentogenin, jugcathanin, and congeners.
The syntheses of myricatomentogenin, jugcathanin, galeon, pterocarine, and acerogenin L are reported. Synthetic material was used to measure their optical activities and free energy of activation forExpand
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Enantioselective Ullmann ether couplings: syntheses of (-)-myricatomentogenin, (-)-jugcathanin, (+)-galeon, and (+)-pterocarine.
The first enantioselective Ullmann cross-coupling reactions to prepare diaryl ethers are reported. The reactions were used to prepare the diarylether heptanoid natural productsExpand
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On the use of differential solubility in aqueous ethanol solutions to narrow the DP range of food-grade starch hydrolysis products.
Considerable research is focused on understanding the functionality of starch hydrolysis products (SHP) consisting of glucose, maltose, maltooligosaccharides (MOS), and maltopolysaccharides (MPS). AExpand
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Oxidative Release of Copper from Pharmacologic Copper Bis(thiosemicarbazonato) Compounds.
Intracellular delivery of therapeutic or analytic copper from copper bis-thiosemicabazonato complexes is generally described in terms of mechanisms involving one-electron reduction to the Cu(I)Expand
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Synthetic studies toward SNF4435 C and SNF4435 D.
[reaction: see text] A synthetic approach toward the immunosuppressants SNF3345 C and SNF4435 D featuring a tandem Stille coupling/electrocyclization cascade is described.
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High-yielding oxidation of β-hydroxyketones to β-diketones using o-iodoxybenzoic acid.
The oxidation of β-hydroxyketones to β-diketones was systematically investigated. o-Iodoxybenzoic acid (IBX) was found to be efficient, operationally easy, and superior to other common oxidants. TheExpand
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Total synthesis of (-)-SNF4435 C and (+)-SNF4435 D.
[reaction: see text] A convergent, biomimetic total synthesis of the immunosuppressant polyketides SNF4435 C and D is described. The synthetic pathway features a stereo- and regioselectiveExpand
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Golgi-modifying properties of macfarlandin E and the synthesis and evaluation of its 2,7-dioxabicyclo[3.2.1]octan-3-one core
Golgi-modifying properties of the spongian diterpene macfarlandin E (MacE) and a synthetic analog, t-Bu-MacE, containing its 2,7-dioxabicyclo[3.2.1]octan-3-one moiety are reported. Natural productExpand
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