Share This Author
Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats
- W. Carlezon, C. Béguin, B. Cohen
- Biology, PsychologyJournal of Pharmacology and Experimental…
- 1 January 2006
SalvA data provide additional support for the hypothesis that stimulation of brain κ-opioid receptors triggers depressive-like signs in rats and raise the possibility that decreases in extracellular concentrations of DA within the NAc contribute to these effects.
Duration of Action of a Broad Range of Selective κ-Opioid Receptor Antagonists Is Positively Correlated with c-Jun N-Terminal Kinase-1 Activation
This work used C57BL/6 wild type mice to determine the durations of antagonist action of novel κ-opioid receptor ligands and examined their efficacies for JNK1 activation compared with conventional competitive antagonists.
Kappa-opioid ligands in the study and treatment of mood disorders.
Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers.
Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats
SalvA and ketamine have previously under-appreciated similarities in their behavioral effects and pharmacological profiles, and KORs might be involved in some of the cognitive abnormalities observed in psychiatric disorders such as schizophrenia.
Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity
The very slow elimination of JDTic from brain is surprising given that it undergoes active efflux, has modest affinity for homogenate, and has a shorter duration of action than nor-BNI under these conditions, and it is proposed that this persistence may result from entrapment in cellular compartments such as lysosomes.
Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues.
Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2).
Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18).