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Antioxidative resuscitation solution prevents leukocyte adhesion in the liver after hemorrhagic shock.
BACKGROUND The generation of iron-dependent toxic oxygen radicals during the initial resuscitation from hemorrhagic shock was shown to be a relevant factor for the initiation of the inflammatoryExpand
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Translation initiation factor eIF‐4G is immunogenic, overexpressed, and amplified in patients with squamous cell lung carcinoma
Recently, the authors reported identification and cloning of several novel immunogenic antigens in squamous cell lung carcinoma. Of 14 corresponding genes, 9 mapped in an amplified chromosomal regionExpand
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Interleukin-1 receptor antagonist attenuates leukocyte-endothelial interactions in the liver after hemorrhagic shock in the rat.
OBJECTIVE To evaluate the influence of interleukin-1 on leukocyte-endothelial cell interactions and the microcirculation in the liver after hemorrhagic shock by means of intravital microscopy usingExpand
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Attenuation of Leukocyte Adhesion by Recombinant TNF-Binding Protein After Hemorrhagic Shock in the Rat
Ischemia/reperfusion injury involves a large number of humoral and cellular mediators that activate leukocytes that subsequently migrate to local tissues. Tumor necrosis factor (TNF)-&agr; may be oneExpand
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Role of nitric oxide in the regulation of the hepatic microcirculation in vivo.
BACKGROUND/AIMS Nitric oxide (NO) is an important mediator in the regulation of vascular tone. However, no data exist on the physiological role of NO in the regulation of the hepaticExpand
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A NATURAL GLYCOPROTEIN INHIBITOR (NIF) OF CD11b/CD18 REDUCES LEUKOCYTE ADHESION IN THE LIVER AFTER HEMORRHAGIC SHOCK
This study was designed to assess the effect of neutrophil inhibitory factor (NIF), a novel specific inhibitor of CD11b/CD18 on hepatic leukocyte trafficking by intravital microscopy 5 h afterExpand
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The Attenuation of Hepatic Microcirculatory Alterations by Exogenous Substitution of Nitric Oxide by S-Nitroso-Human Albumin After Hemorrhagic Shock in the Rat
Hepatic microcirculatory disorders such as narrowing of sinusoids after hemorrhagic shock play a major role in the pathogenesis of organ failure. It is known that the balance of vasoactive mediatorsExpand
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Recombinant N-terminal fragment of bactericidal/permeability increasing protein (rBPI21) prevents shock-induced microcirculatory alterations in the liver.
OBJECTIVE To investigate the effects of the recombinant 21-kilodalton N-terminal fragment of recombinant bactericidal and permeability increasing protein (rBPI21) on leukocyte adhesion and theExpand
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Adenosine kinase inhibitor GP515 attenuates hepatic leukocyte adhesion after hemorrhagic hypotension.
Adhesion of leukocytes to the vascular endothelium hallmarks a key event in neutrophil-mediated organ injury after ischemia-reperfusion. The autacoid adenosine has been shown to inhibit activatedExpand
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Evidence for a Sustained Inflammatory Response of the Hepatic Microcirculation after Hemorrhagic Shock
Defined microcirculatory disturbances have been demonstrated during the first hours after hemorrhagic shock involving complex pathophysiological mechanisms. Since clinical complications associatedExpand
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