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Protective effect of melatonin against human leukocyte apoptosis induced by intracellular calcium overload: relation with its antioxidant actions
TLDR
Melatonin treatment substantially prevented intracellular ROS production, reversed caspase activation, and forestalled DNA fragmentation induced by TG and FMLP, helping to understand how melatonin controls apoptosis in cells of immune/inflammatory relevance. Expand
Melatonin induces mitochondrial‐mediated apoptosis in human myeloid HL‐60 cells
TLDR
It is concluded that melatonin has proapoptotic and/or oncostatic effects in the human myeloid cell line HL‐60, and the exposure of cells to melatonin resulted in an activation and association of the proAPoptotic proteins Bax and Bid, as well as promoting detectable increases in the expression of both proteins. Expand
Melatonin Reduces Apoptosis Induced by Calcium Signaling in Human Leukocytes: Evidence for the Involvement of Mitochondria and Bax Activation
TLDR
The results suggest that melatonin reduces caspase-9 and -3 activities induced by increases in [Ca2+]c in human leukocytes, which are produced through the inhibition of both mPTP and Bax activation. Expand
Pro-oxidant effect of melatonin in tumour leucocytes: relation with its cytotoxic and pro-apoptotic effects.
TLDR
Pre-treatment of cells with well-known antioxidants, such as N-acetyl-L-cysteine (NAC), trolox, PEG-catalase and reduced glutathione (GSH), reversed the effects of melatonin on both intracellular ROS production, as on the cytotoxicity and caspase activation, which may assist in limiting tumour cell growth. Expand
Correlation between the circadian rhythm of melatonin, phagocytosis, and superoxide anion levels in ring dove heterophils
TLDR
The findings show that one pineal‐mediated effect on the immune system may be a direct action of melatonin onphagocytosis and the phagocytic biochemical process, and that this neurohormone might act as an antioxidant. Expand
Melatonin reduces body weight gain and increases nocturnal activity in male Wistar rats
TLDR
Exogenous melatonin reduces body weight gain without having marked effects on metabolism and increases nocturnal locomotor activity in male Wistar rats treated with the indoleamine. Expand
Circadian levels of serotonin in plasma and brain after oral administration of tryptophan in rats.
TLDR
Oral administration of tryptophan during 7 days enhances serotonin levels over a 24-hr period, and produces an advance in the peak of serotonin in both plasma and different brain regions. Expand
Phagocytic function of blood neutrophils in sedentary young people after physical exercise.
TLDR
Opsonization of Candida albicans as well as candidicide power increased significantly in men and women after exercise, and the immediate advantages of physical exercise on the phagocytic immune response is discussed. Expand
The circadian rhythm of tryptophan in breast milk affects the rhythms of 6-sulfatoxymelatonin and sleep in newborn.
TLDR
A temporal relationship was observed between the circadian rhythm of 6-sulfatoxymelatonin of the exclusively breast-fed babies and that of tryptophan in the mother's milk, and assumed sleep, actual sleep, and sleep efficiency were significantly increased in the breast fed infants with respect the formula fed infants. Expand
Jerte Valley cherry-enriched diets improve nocturnal rest and increase 6-sulfatoxymelatonin and total antioxidant capacity in the urine of middle-aged and elderly humans.
TLDR
It is suggested that the intake of Jerte Valley cherries exerted positive effect on sleep and may be seen as a potential nutraceutical tool to counteract oxidation. Expand
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