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Theta phase precession in hippocampal neuronal populations and the compression of temporal sequences
Large‐scale parallel recordings are made use of to clarify and extend the finding that a cell's spike activity advances to earlier phases of the theta cycle as the rat passes through the cell's place field, and to show Granule cells of the fascia dentata are also modulated by theta.
Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.
- C. Barnes
- Biology, PsychologyJournal of comparative and physiological…
- 1 February 1979
The amount of synaptic enhancement was statistically correlated with the ability to perform the circular platform task both within and between groups, and the aftereffects of the high-frequency stimulation selectively impaired the old rats' spontaneous alternation behavior on a T-maze.
Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites
Inhibition of Activity-Dependent Arc Protein Expression in the Rat Hippocampus Impairs the Maintenance of Long-Term Potentiation and the Consolidation of Long-Term Memory
Investigation of the role of the IEGArc in hippocampal plasticity shows that disruption of Arc protein expression impairs the maintenance phase of LTP without affecting its induction and impairs consolidation of LTM for spatial water task training without affecting task acquisition or short-term memory.
Homer: a protein that selectively binds metabotropic glutamate receptors
A novel dendritic protein, Homer, is reported that contains a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked metabotropic glutamate receptors, suggesting that Homer mediates a novel cellular mechanism that regulates glutamate signalling.
Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles
Following sequential exposure of rats to two different environments or to the same environment twice, the proportion of CA1 neurons with cytoplasmic, nuclear or overlapping Arc expression profiles matched predictions derived from ensemble neurophysiological recordings of hippocampal neuronal ensembles.
Deciphering the hippocampal polyglot: the hippocampus as a path integration system.
A hypothesis of how the path integration system may operate at the neuronal level is proposed, and it appears that viewpoint-specific visual information becomes secondarily bound to this structure by associative learning.
Reactivation of Hippocampal Cell Assemblies: Effects of Behavioral State, Experience, and EEG Dynamics
Pattern reinstatement was strongest during sharp wave–ripple oscillations, suggesting that these events may reflect system convergence onto attractor states corresponding to previous experiences, and do not necessarily reflect persistence of an active memory.
Interactions between location and task affect the spatial and directional firing of hippocampal neurons
- EJ Markus, YL Qin, B. Leonard, WE Skaggs, B. McNaughton, C. Barnes
- Biology, PsychologyThe Journal of neuroscience : the official…
- 1 November 1995
H hippocampal neuronal activity appears to encode a complex interaction between locations, their significance and the behaviors the rat is called upon to execute.