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Theta phase precession in hippocampal neuronal populations and the compression of temporal sequences
O'Keefe and Recce [1993] Hippocampus 3:317–330 described an interaction between the hippocampal theta rhythm and the spatial firing of pyramidal cells in the CA1 region of the rat hippocampus: theyExpand
Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites
Neuronal activity is an essential stimulus for induction of plasticity and normal development of the CNS. We have used differential cloning techniques to identify a novel immediate-early gene (IEG)Expand
Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.
  • C. Barnes
  • Psychology, Medicine
  • Journal of comparative and physiological…
  • 1 February 1979
Neurophysiological and behavioral measures were obtained from 32 senescent (28--34 mo) and 32 mature adult (10--16 mo) rats. Extracellularly recorded synaptic responses were obtained from electrodesExpand
Homer: a protein that selectively binds metabotropic glutamate receptors
Spatial localization and clustering of membrane proteins is critical to neuronal development and synaptic plasticity. Recent studies have identified a family of proteins, the PDZ proteins, thatExpand
Inhibition of Activity-Dependent Arc Protein Expression in the Rat Hippocampus Impairs the Maintenance of Long-Term Potentiation and the Consolidation of Long-Term Memory
It is widely believed that the brain processes information and stores memories by modifying and stabilizing synaptic connections between neurons. In experimental models of synaptic plasticity, suchExpand
Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles
We used fluorescent in-situ hybridization and confocal microscopy to monitor the subcellular distribution of the immediate-early gene Arc. Arc RNA appeared in discrete intranuclear foci withinExpand
Deciphering the hippocampal polyglot: the hippocampus as a path integration system.
Hippocampal 'place' cells and the head-direction cells of the dorsal presubiculum and related neocortical and thalamic areas appear to be part of a preconfigured network that generates an abstract internal representation of two-dimensional space whose metric is self-motion. Expand
Reactivation of Hippocampal Cell Assemblies: Effects of Behavioral State, Experience, and EEG Dynamics
During slow wave sleep (SWS), traces of neuronal activity patterns from preceding behavior can be observed in rat hippocampus and neocortex. The spontaneous reactivation of these patterns isExpand
Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
Prostaglandins play important and diverse roles in the CNS. The first step in prostaglandin synthesis involves enzymatic oxidation of arachidonic acid, which is catalyzed by prostaglandin H(PGH)Expand
Interactions between location and task affect the spatial and directional firing of hippocampal neurons
When rats forage for randomly dispersed food in a high walled cylinder the firing of their hippocampal “place” cells exhibits little dependence on the direction faced by the rat. Expand