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Niche-specific regulation of central metabolic pathways in a fungal pathogen
To establish an infection, the pathogen Candida albicans must assimilate carbon and grow in its mammalian host. This fungus assimilates six‐carbon compounds via the glycolytic pathway, and two‐carbonExpand
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GFP as a quantitative reporter of gene regulation in Candida albicans
A system has been developed for the quantitative analysis of gene expression within individual Candida albicans cells in infected tissue. The system is based on the plasmid pGFP, which contains theExpand
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CIp10, an efficient and convenient integrating vector for Candida albicans
Candida albicans is the major fungal pathogenin humans (Odds, 1994). Despite its medicalimportance, the molecular dissection of thisfungus has progressed relatively slowly. This isbecause (a) it isExpand
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Exposure of Candida albicans to antifungal agents affects expression of SAP2 and SAP9 secreted proteinase genes.
OBJECTIVES To ascertain the effects of subinhibitory concentrations of several antifungal agents on a virulence factor: secreted proteinase (Sap) activity and expression of SAP genes in CandidaExpand
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Shark variable new antigen receptor biologics – a novel technology platform for therapeutic drug development
Introduction: Biologics drugs have succeeded in achieving a commercial dominance in the global market for new therapies and large pharmaceutical companies' interest remains strong through a continuedExpand
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Therapeutic Potential of Shark Anti-ICOSL VNAR Domains is Exemplified in a Murine Model of Autoimmune Non-Infectious Uveitis
Induced costimulatory ligand (ICOSL) plays an important role in the activation of T cells through its interaction with the inducible costimulator, ICOS. Suppression of full T cell activation can beExpand
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Asynchronous Cell Cycle and Asymmetric Vacuolar Inheritance in True Hyphae of Candida albicans
ABSTRACT Candida albicans forms unconstricted hyphae in serum-containing medium that are divided into discrete compartments. Time-lapse photomicroscopy, flow cytometry, and a novel three-dimensionalExpand
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Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias).
The cartilaginous fish (chimeras, sharks, skates and rays) are the oldest group relative to mammals in which an adaptive immune system founded upon immunoglobulins has been found. In this manuscriptExpand
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Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy
Chronic liver disease results in a liver-scarring response termed fibrosis. Excessive scarring leads to cirrhosis, which is associated with high morbidity and mortality. The only treatment for liverExpand
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