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Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains.
The functional significance of mono-, di-, and trimethylation of lysine residues within histone proteins remains unclear. Antibodies developed to selectively recognize each of these methylated statesExpand
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Differential regulation of CENP-A and histone H3 phosphorylation in G2/M.
After DNA replication, cells condense their chromosomes in order to segregate them during mitosis. The condensation process as well as subsequent segregation requires phosphorylation of histone H3 atExpand
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Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.
Endothelium-derived relaxing factor (EDRF), identified as nitric oxide (NO), is derived from a guanidino nitrogen of L-arginine via its metabolism by nitric oxide synthase (NOS). Herein, we reportExpand
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Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry.
Histone H1 isoforms isolated from asynchronously grown HeLa cells were subjected to enzymatic digestion and analyzed by nano-flow reversed-phase high performance liquid chromatography (RP-HPLC)Expand
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The enhancement of histone H4 and H2A serine 1 phosphorylation during mitosis and S-phase is evolutionarily conserved
Histone phosphorylation has long been associated with condensed mitotic chromatin; however, the functional roles of these modifications are not yet understood. Histones H1 and H3 are highlyExpand
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RTA, a candidate G protein-coupled receptor: cloning, sequencing, and tissue distribution.
Genomic and cDNA clones, encoding a protein that is a member of the guanine nucleotide-binding regulatory protein (G protein)-coupled receptor superfamily, were isolated by screening rat genomic andExpand
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Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein.
Endothelial cell nitric oxide synthase (ECNOS) is a membrane-associated enzyme that generates endothelium-derived relaxing factor/nitric oxide (EDRF/NO) from L-arginine. We have suggested, from theExpand
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Modifications of human histone H3 variants during mitosis.
Phosphorylation of histone H3 is a hallmark event in mitosis and is associated with chromosome condensation. Here, we use a combination of immobilized metal affinity chromatography and tandem massExpand
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Molecular cloning of a novel rat G‐protein‐coupled receptor gene expressed prominently in lung, adrenal, and liver
A gene and cDNA (named G10d) encoding a novel member of the G‐protein‐coupled receptor (GCR) superfamily has been isolated from a rat genomic library and a rat liver cDNA library by tandom polymeraseExpand
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Molecular characterization of a rat alpha 2B-adrenergic receptor.
Alpha 2-adrenergic receptors comprise a heterogeneous population based on pharmacologic and molecular evidence. We have isolated a cDNA clone (pRNG alpha 2) encoding a rat alpha 2-adrenergicExpand
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