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Contact with a component of the polymerase II holoenzyme suffices for gene activation
TLDR
It is proposed that a single activator-holoenzyme contact can trigger gene activation simply by recruiting the latter to DNA. Expand
A self-assembled monolayer for the binding and study of histidine-tagged proteins by surface plasmon resonance.
TLDR
Surface plasmon resonance studies showed that His-tagged proteins adsorbed on the NTA-SAM retained a greater ability to participate in binding interactions with proteins in solution than protein immobilized in a thin dextran gel layer by covalent coupling. Expand
A Minimal Fragment of MUC1 Mediates Growth of Cancer Cells
TLDR
Evidence is presented that strongly supports a mechanism whereby dimerization of the extracellular domain of MUC1* activates the MAP kinase signaling cascade and stimulates cell growth, and methods to manipulate this growth mechanism for therapeutic interventions in cancer treatments are suggested. Expand
MUC1* is a determinant of trastuzumab (Herceptin) resistance in breast cancer cells
TLDR
Molecular analysis of a cancer cell line that was induced to acquire trastuzumab resistance showed a dramatic increase in the amount of the cleaved form of the MUC1 protein, which functions as a growth factor receptor on cancer cells and on embryonic stem cells. Expand
MUC1* Mediates the Growth of Human Pluripotent Stem Cells
TLDR
It is reported that MUC1* acts as a growth factor receptor on undifferentiated human embryonic stem cells (hESCs) and this primal growth mechanism could be utilized to propagate large numbers of pluripotent stem cells for therapeutic interventions. Expand
A Primitive Growth Factor, NME7AB, Is Sufficient to Induce Stable Naïve State Human Pluripotency; Reprogramming in This Novel Growth Factor Confers Superior Differentiation
TLDR
A mechanistic model of how human stem cells regulate self-replication is suggested: an early naïve state driven by NME7, which cannot itself limit self‐replication and a later naïve state regulated byNME1, which limits self‐Replication when its multimerization state shifts from the active dimer to the inactive hexamer. Expand
Electron Transfer at Electrodes through Conjugated “Molecular Wire” Bridges
Electron-transfer rates and electronic coupling factors for ferrocene groups attached to gold electrodes via oligo(phenylethynyl) “molecular wire” bridges of variable length and structure areExpand
A Minimal Set of RNA Polymerase II Transcription Protein Interactions*
TLDR
Point mutations inTFIIB that alter the location of transcription start sites in vivo markedly diminished the affinity of TFIIB binding to RNA polymerase II, suggesting that these four interactions constitute a minimal set for the formation of a transcription initiation complex. Expand
The use of variable density self-assembled monolayers to probe the structure of a target molecule.
  • C. Bamdad
  • Biology, Medicine
  • Biophysical journal
  • 1 October 1998
TLDR
The results favor mechanistic model 1: reiterated activation motifs interact with TBP through a high-affinity interaction that is the result of the cooperative effect of single motifs simultaneously binding to separate sites on TBP. Expand
A DNA self-assembled monolayer for the specific attachment of unmodified double- or single-stranded DNA.
  • C. Bamdad
  • Chemistry, Medicine
  • Biophysical journal
  • 1 October 1998
A novel method for DNA surface immobilization and a paradigm for the attachment of unmodified DNA of any length or sequence are described herein. The development of a DNA self-assembled monolayerExpand
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