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Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells
Interestingly, double color, time-lapse movies visualizing both paxillin and zyxin, indicated that the transition frompaxillin-rich focal complexes to definitive,Zyxin-containing focal adhesions, takes place only after the leading edge stops advancing or retracts, illuminating, for the first time, early stages in focal complex assembly and the dynamic process associated with its transformation into focal adhesion. Expand
Vinculin controls focal adhesion formation by direct interactions with talin and actin
The vinculin head regulates integrin dynamics and clustering and the tail regulates the link to the mechanotransduction force machinery, which is responsible for the functional link of FAs to the actin cytoskeleton. Expand
Cell behaviour on micropatterned substrata: limits of extracellular matrix geometry for spreading and adhesion
Knowing the geometrical limits of ECM binding sites required for cell attachment and spreading is essential for an understanding of cell adhesion and migration, and for the design of artificial surfaces that optimally interact with cells in a living tissue. Expand
Endocytic vesicles move at the tips of actin tails in cultured mast cells
This research presents a new probabilistic procedure that allows us to assess the immune status of the central nervous system through the excursion of the Tournaisian nervous system. Expand
Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner
It is shown that vinculin, through its links to the talin-integrin complex and F-actin, regulates the transmission of mechanical signals from the extracellular matrix to the actomyosin machinery, leading to the reorganization of cell polarity. Expand
Marching at the front and dragging behind
Integrins are cell–substrate adhesion molecules that provide the essential link between the actin cytoskeleton and the extracellular matrix during cell migration. We have analyzed αVβ3-integrinExpand
JAM-2, a Novel Immunoglobulin Superfamily Molecule, Expressed by Endothelial and Lymphatic Cells*
The results suggest that JAM-2 is a novel vascular molecule, which participates in interendothelial junctional complexes, and the role of the protein in the sealing of cell-cell contact is suggested. Expand
Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6
The physical presence of HDAC6 with impaired catalytic activity, rather than tubulin acetylation per se, is the factor responsible for the alteration of microtubule growth velocity inHDAC6 inhibitor-treated cells. Expand
Actin dynamics in living mammalian cells.
The enhanced green fluorescent protein (EGFP) was fused to human &bgr ;-actin and expressed in living cells unveiled structures involved in the dynamics of the actin cytoskeleton. Expand
Syndecan-4–dependent Rac1 regulation determines directional migration in response to the extracellular matrix
Using nano-engineered fibronectin surfaces and cell-derived matrices, syndecan-4 is identified as a key signaling receptor determining directional migration that mediates the matrix-induced protein kinase Cα–dependent activation of Rac1 and localizes Rac1 activity and membrane protrusion to the leading edge of the cell, resulting in persistent migration. Expand