• Publications
  • Influence
The Role of Adipose Tissue and Adipokines in Obesity-Related Inflammatory Diseases
Obesity is an energy-rich condition associated with overnutrition, which impairs systemic metabolic homeostasis and elicits stress. It also activates an inflammatory process in metabolically activeExpand
  • 328
  • 27
  • Open Access
Inflammatory networks in ageing, age-related diseases and longevity
Inflammation is considered a response set by the tissues in response to injury elicited by trauma or infection. It is a complex network of molecular and cellular interactions that facilitates aExpand
  • 401
  • 12
Inflammation, genes and zinc in Alzheimer's disease
Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disease which in Western society mainly accounts for clinical dementia. AD has been linked to inflammation and metalExpand
  • 101
  • 6
CCR5 Receptor
Abstract:  The CC chemokine receptor 5 (CCR5) is a member of CC‐chemokine receptor family. CCR5 has the characteristic structure of a seven transmembrane G protein–coupled receptor (GPCR), whichExpand
  • 73
  • 4
Granulocyte and natural killer activity in the elderly
The deterioration of the immune system in ageing, 'immunosenescence', is thought to contribute to increased morbidity and mortality from infections and possibly autoimmune diseases and cancer. TheExpand
  • 88
  • 3
Association between +1059G/C CRP Polymorphism and Acute Myocardial Infarction in a Cohort of Patients from Sicily
Abstract:  Inflammation plays a role in all the phases of atherosclerosis, and increased production of the acute‐phase reactant, C‐reactive protein (CRP), predicts future cardiovascular events.Expand
  • 29
  • 3
Biology of longevity: role of the innate immune system.
Genetic factors play a relevant role in the attainment of longevity because they are involved in cell maintenance systems, including the immune system. In fact, longevity may be correlated withExpand
  • 86
  • 2
TLR4 Polymorphisms and Ageing: Implications for the Pathophysiology of Age-Related Diseases
IntroductionInnate immunity provides a first line of host defense against infection by recognizing and killing microbes while simultaneously activating an instructive immune response. Toll-likeExpand
  • 101
  • 2
Association between the MHC class I gene HFE polymorphisms and longevity: a study in Sicilian population
Classes I and II human leukocyte antigens (HLA) genes encode highly polymorphic heterodimeric glycoproteins involved in the control of immune responses. The HLA class I gene HFE seemingly no longerExpand
  • 54
  • 2
Polymorphisms of pro-inflammatory genes and prostate cancer risk: a pharmacogenomic approach
In this paper, we consider the role of the genetics of inflammation in the pathophysiology of prostate cancer (PCa). This paper is not an extensive review of the literature, rather it is an expertExpand
  • 34
  • 2