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Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors
Macrophages (mφ) are essential for intestinal homeostasis and the pathology of inflammatory bowel disease (IBD), but it is unclear whether discrete mφ populations carry out these distinct functionsExpand
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CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis.
Dendritic cells (DCs) and monocyte-derived macrophages (MΦs) are key components of intestinal immunity. However, the lack of surface markers differentiating MΦs from DCs has hampered understanding ofExpand
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Correction: Corrigendum: Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice
Nat. Immunol. doi:10.1038/ni.2967 corrected online 8 September 2014 In the version of this article initially published online, the vertical axis of the bottom right graph in Figure 3h was incorrect.Expand
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Macrophages in intestinal homeostasis and inflammation
The intestine contains the largest pool of macrophages in the body which are essential for maintaining mucosal homeostasis in the face of the microbiota and the constant need for epithelial renewalExpand
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Mucosal Macrophages in Intestinal Homeostasis and Inflammation
  • A. Mowat, C. Bain
  • Medicine, Biology
  • Journal of Innate Immunity
  • 19 September 2011
Intestinal macrophages are essential for local homeostasis and in keeping a balance between commensal microbiota and the host. However, they also play essential roles in inflammation and protectiveExpand
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Type 2 Innate Lymphoid Cells Drive CD4+ Th2 Cell Responses
CD4+ T cells have long been grouped into distinct helper subsets on the basis of their cytokine-secretion profile. In recent years, several subsets of innate lymphoid cell have been described as keyExpand
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Intestinal macrophages and dendritic cells: what's the difference?
Mononuclear phagocytes (MPs) in the murine intestine, comprising dendritic cells (DCs) and macrophages (Mϕs), perform disparate yet complementary immunological functions. Functional analyses of theseExpand
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An Independent Subset of TLR Expressing CCR2-Dependent Macrophages Promotes Colonic Inflammation
Macrophages (Mϕs) in the large intestine are crucial effectors of inflammatory bowel disease, but are also essential for homeostasis. It is unclear if these reflect separate populations of Mϕs or ifExpand
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CCR2+CD103− intestinal dendritic cells develop from DC-committed precursors and induce interleukin-17 production by T cells
The identification of intestinal macrophages (mφs) and dendritic cells (DCs) is a matter of intense debate. Although CD103+ mononuclear phagocytes (MPs) appear to be genuine DCs, the nature andExpand
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The monocyte-macrophage axis in the intestine
Highlights • Mϕ are involved in gut homeostasis and the pathogenesis of intestinal inflammation.• Resident and proinflammatory intestinal Mϕ both derive from Ly6Chi blood monocytes.• LocalExpand
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