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Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition.
Glass DNA microarrays used to investigate the transcription profiles of 6333 predicted ORFs in cells undergoing this transition and their responses to changes in temperature and culture medium identified transcripts that are induced before germ tube initiation and shut off later in the developmental process.
Morphogenesis in Candida albicans.
Recent studies are beginning to shed light on some of the molecular controls regulating the various morphogenetic forms of this fascinating human pathogen.
Genome-Wide Fitness Test and Mechanism-of-Action Studies of Inhibitory Compounds in Candida albicans
Candida albicans is a prevalent fungal pathogen amongst the immunocompromised population, causing both superficial and life-threatening infections. Since C. albicans is diploid, classical…
Depletion of a polo-like kinase in Candida albicans activates cyclase-dependent hyphal-like growth.
The identified CaCDC5, a cell cycle regulatory polo-like kinase (PLK) in C. albicans and demonstrated that shutting off its expression induced cell cycle defects and dramatic changes in morphology, suggesting an internal, cell cycle-related cue can activate hyphal regulatory networks in Candida.
Cell cycle arrest during S or M phase generates polarized growth via distinct signals in Candida albicans
Different gene expression patterns during early stages of cell elongation support the concept that CaCdc5p‐depleted and HU‐exposed cells were blocked at different stages of the cell cycle, and suggest that different signals may generate the common polarized growth phenotype.
Cyclin Cln3p Links G1 Progression to Hyphal and Pseudohyphal Development in Candida albicans
The data suggest that the G1 phase of the cell cycle may play a critical role in regulating hyphal and pseudohyphal development in C. albicans and uncouple differentiation from the normal environmental controls.
A Human-Curated Annotation of the Candida albicans Genome
Improved annotation permitted a detailed analysis of several multigene families, and comparative genomic studies showed that C. albicans has a far greater catabolic range, encoding respiratory Complex 1, several novel oxidoreductases and ketone body degrading enzymes, malonyl- CoA and enoyl-CoA carriers, and numerous transporters to assimilate the resulting nutrients.
Radial F-actin arrays precede new hypha formation in Saprolegnia: implications for establishing polar growth and regulating tip morphogenesis.
F-actin participates in initiating tip formation in addition to its previously demonstrated participation in maintenance of hyphal tip growth, and the results are consistent with F-Actin regulating polar vesicle delivery and controlling vesicles fusion at the plasma membrane, and suggest that F-act in participates in establishing polar growth.
Orthologues of the Anaphase-Promoting Complex/Cyclosome Coactivators Cdc20p and Cdh1p Are Important for Mitotic Progression and Morphogenesis in Candida albicans
The results suggest that Cdc20p and Cdh1p may be APC/C activators that are important for mitosis but also morphogenesis in C. albicans and imply additional variations in function and underscore rewiring in the emerging mitotic regulatory networks of the pathogen.
G1/S Transcription Factor Orthologues Swi4p and Swi6p Are Important but Not Essential for Cell Proliferation and Influence Hyphal Development in the Fungal Pathogen Candida albicans
The data suggest that the putative G1/S regulatory machinery of C. albicans contains novel features and underscore the existence of a relationship between G1 phase and morphogenetic switching, including hyphal development, in the pathogen.