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Characterization of a mouse strain expressing Cre recombinase from the 3′ untranslated region of the dopamine transporter locus
This knockin mouse can be used for generating tissue specific knockouts in mice carrying genes flanked by loxP sites, and will facilitate the analysis of gene function in dopaminergic neurons.
A selective group of dopaminergic neurons express Nurr1 in the adult mouse brain
Nogo receptor 1 regulates formation of lasting memories
- Alexandra Karlén, Tobias Karlsson, L. Olson
- Biology, PsychologyProceedings of the National Academy of Sciences
- 1 December 2009
It is shown that mice with inducible overexpression of NgR1 in forebrain neurons have normal long-term potentiation and normal 24-h memory, but severely impaired month-long memory in both passive avoidance and swim maze tests, and blocking transgene expression normalizes these memory impairments.
Blood-brain barrier penetration and in vivo activity of an NGF conjugate.
Nerve growth factor (NGF) is essential for the survival of both peripheral ganglion cells and central cholinergic neurons of the basal forebrain. The accelerated loss of central cholinergic neurons…
Effects of cerebral ischemia in mice deficient in Persephin
These data indicate that PSP is a potent modulator of excitotoxicity in the central nervous system with pronounced neuroprotective activity and support the view that PSP signaling can exert an important control function in the context of stroke and glutamate-mediated neurotoxicity.
NMDA Receptors on Non-Dopaminergic Neurons in the VTA Support Cocaine Sensitization
It is demonstrated that the NMDA receptor gene is ablated in the majority of VTA DA neurons, including those exhibiting undetectable DAT expression levels in the NR1DATCre transgenic model, and that application of an NMDAR antagonist within the VTA of NR1 DATCre animals still blocks sensitization to cocaine.
Selective Deletion of PTEN in Dopamine Neurons Leads to Trophic Effects and Adaptation of Striatal Medium Spiny Projecting Neurons
Results provide further evidence about the role of PTEN in the brain and suggest that manipulation of the PTEN/Akt signaling pathway during development may alter the basal state of dopaminergic neurotransmission and could provide a therapeutic strategy for the treatment of Parkinson's disease, and other neurodegenerative disorders.
Prefrontal Cortical Kappa-Opioid Receptor Modulation of Local Neurotransmission and Conditioned Place Aversion
It is demonstrated that mPFC KORs negatively regulate DA and amino-acid neurotransmission, and are necessary for KOR-mediated aversion.
Kappa Opioid Receptors on Dopaminergic Neurons Are Necessary for Kappa-Mediated Place Aversion
- V. Chefer, C. Bäckman, E. Gigante, T. Shippenberg
- Biology, PsychologyNeuropsychopharmacology
- 18 July 2013
Intra- ventral tegmental area (VTA) delivery of KORs using an adeno-associated viral gene construct resulted in phenotypic rescue of the KOR-mediated NAc DA response and aversive behavior in DATCre-KOR KO animals, providing evidence that K ORs on VTA DA neurons are necessary to mediate K OR-mediated aversive behaviors.