• Publications
  • Influence
Severe Acquired Toxoplasmosis in Immunocompetent Adult Patients in French Guiana
ABSTRACT The most common presentation of symptomatic postnatally acquired toxoplasmosis in immunocompetent patients is painless cervical adenopathy. Acute visceral manifestations are associated inExpand
International Study to Evaluate PCR Methods for Detection of Trypanosoma cruzi DNA in Blood Samples from Chagas Disease Patients
This study represents a first crucial step towards international validation of PCR procedures for detection of T. cruzi in human blood samples by an external quality evaluation. Expand
Fatal outbreak of human toxoplasmosis along the Maroni River: epidemiological, clinical, and parasitological aspects.
Molecular analysis demonstrated that identical isolates of only 1 atypical strain were responsible for at least 5 of the 11 cases of toxoplasmosis in the outbreak in Patam, a Surinamese village near the French Guianan border. Expand
Integrate study of a Bolivian population infected by Trypanosoma cruzi, the agent of Chagas disease.
A cross section of a human population selected at random, and living in a Bolivian community, highly endemic for Chagas disease, was investigated combining together clinical, parasitological and molecular approaches, finding the anti-R13 reactivity was associated with early infection and not to cardiac pathology. Expand
Trypanosoma cruzi I genotypes in different geographical regions and transmission cycles based on a microsatellite motif of the intergenic spacer of spliced-leader genes.
The intergenic region of spliced-leader (SL-IR) genes from 105 Trypanosoma cruzi I infected biological samples, culture isolates and stocks from 11 endemic countries were characterised, allowing identification of 76 genotypes with 54 polymorphic sites from 123 aligned sequences. Expand
American histoplasmosis in developing countries with a special focus on patients with HIV: diagnosis, treatment, and prognosis
Direct examination of May–Grünwald–Giemsa-stained smears or tissues in suspected histoplasmosis is a simple means of confirming the diagnosis in resource-poor settings and further refine indication criteria to guide first-line treatment choice between amphotericin B and itraconazole. Expand
Ecologic Correlates of Toxoplasma gondii Exposure in Free-ranging Neotropical Mammals
A serologic survey for Toxoplasma gondii in 18 free-ranging forest mammal species in French Guiana was undertaken with a direct agglutination test and terrestrial mammals were significantly more exposed to T. Gondii than other mammals. Expand
Histoplasmosis and acquired immunodeficiency syndrome: a study of prognostic factors.
It is found that dyspnea, a platelet count of <100,000 platelets/mm3, and lactate dehydrogenase levels of >2 times the upper limit of the normal range were significantly independently associated with the death of the patient during the first 30 days of antifungal treatment. Expand
Histoplasmosis in HIV-Infected Patients: A Review of New Developments and Remaining Gaps
Progress has been made in DNA patterns of strains and understanding of pathogenesis, and hopefully these will help identify new therapeutic targets and new diagnostic tools and therapeutics developments have still not been made available in most endemic regions. Expand
Serologic survey of Toxoplasma gondii in noncarnivorous free-ranging neotropical mammals in French Guiana.
It is concluded that wild mammals in French Guiana constitute a reservoir of T. gondii parasites, and noncarnivorous species may be infected by the ingestion of oocysts that are eliminated into the soil or water in the stools of wild cats and then dispersed. Expand