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Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.
It is demonstrated that piperine is a nonspecific inhibitor of drug metabolism which shows little discrimination between different cytochrome P-450 forms. Expand
Immunomodulating agents of plant origin. I: Preliminary screening.
- C. Atal, M. Sharma, A. Kaul, A. Khajuria
- Biology, Medicine
- Journal of ethnopharmacology
- 1 November 1986
The immunobiological activity was investigated of certain medicinal plants widely used in the Ayurvedic and Unani systems of medicine for treatment of chronic infections and immunological disorders and Picrorhiza kurroa was found to be a potent immunostimulant, stimulating both cell-mediated and humoral immunity. Expand
Scientific evidence on the role of Ayurvedic herbals on bioavailability of drugs.
It appears that the trikatu group of drugs increase bioavailability either by promoting rapid absorption from the gastrointestinal tract, or by protecting the drug from being metabolised/oxidised in its first passage through the liver after being absorbed,or by a combination of these two mechanisms. Expand
Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis.
Insect Antifertility and Antifeedant Allelochemics in Adhatoda Vasica
Various alkaloids from Adhatoda vasica (Acanthaceae) were found to be responsible for the antifertility and antifeedant activity of the extracts of the plant against insects and appear to show a dual activity vis-à-vis a species specificity. Expand
Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new non-steroidal anti-inflammatory agent
In formaldehyde and adjuvant arthritis, AESG produced prominent anti-arthritic activity but no significant effect was observed in cotton pellet-induced granuloma test and it inhibited inflammation induced increase in serum transaminase levels and leucocyte counts but lacked any analgesic or anti-pyretic effects. Expand
Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogeneous UDP-glucuronic acid content.
- J. Singh, R. Dubey, C. Atal
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 February 1986
The studies demonstrate that piperine modifies the rate of glucuronidation by lowering the endogeneous UDP-glucuronic acid content and also by inhibiting the transferase activity. Expand
The chemistry of Indian Piper species.
Protective effect of Tinospora cardiofola miers on carbon Tetrachloride induced hepatotoxicity
1. Tinospora cardifolia Miers is reputed to possess beneficial effects in liver ailments in Ayurvedic medicine. 2. Aqueous suspension of alcoholic extract was subjected to pharmacological… Expand
Non-narcotic orally effective, centrally acting analgesic from an Ayurvedic drug.
It can be concluded that high oral efficacy and non-narcotic properties of the test drug make it more acceptable than morphine and lack of any adverse effects, high therapeutic index and absence of abstinence syndrome confers a long term safety on potassium embelate for use as an analgesic. Expand