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Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.
Phosphatidylinositol-3-kinase is an important enzyme for intracellular signaling. The microbial product wortmannin and some of its analogues have been shown to be potent inhibitors ofExpand
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Isolation and characterization of the principal ATPase associated with transitional endoplasmic reticulum of rat liver
The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of theExpand
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Kinase inhibitors from Polygonum cuspidatum.
Bioassay-directed fractionation of a medicinal plant, Polygonum cuspidatum (Polygonaceae), has led to the discovery of a hydroxystilbene, resveratrol [1], as an inhibitor of a protein-tyrosine kinaseExpand
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Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by
Application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin results in a large and rapid induction of epidermal ornithine decarboxylase (ODC; EC activity, a phenotypic changeExpand
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Signaling through mitogen-activated protein kinase and Rac/Rho does not duplicate the effects of activated Ras on skeletal myogenesis.
The ability of basic helix-loop-helix muscle regulatory factors (MRFs), such as MyoD, to convert nonmuscle cells to a myogenic lineage is regulated by numerous growth factor and oncoprotein signalingExpand
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Characterization of the in Vivo Sites of Serine Phosphorylation on Lck Identifying Serine 59 as a Site of Mitotic Phosphorylation*
The lymphocyte-specific protein-tyrosine kinase Lck plays a critical role in T cell activation. In response to T cell antigen receptor binding Lck undergoes phosphorylation on serine residues thatExpand
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Synthesis and MEK1 inhibitory activities of imido-substituted 2-chloro-1,4-naphthoquinones.
Mitogen activated protein kinases are of interest as research tools and as therapeutic target for certain physiological disorders. In this study, we foundExpand
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Aluminum negatively impacts calcium utilization and bone in calcium-deficient rats
Abstract Three studies were designed to investigate the mechanism of aluminum on calcium metabolism. An acute dose of dietary aluminum did not affect calcium absorption in rats. In the second study,Expand
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The phorbol ester receptor: a phospholipid-regulated protein kinase.
  • C. Ashendel
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 9 September 1985
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Protein kinase activity associated with a phorbol ester receptor purified from mouse brain.
Protein kinase activity copurified with the receptor for 12-O-[3H]tetradecanoylphorbol-13-acetate during its purification from mouse brain particulate protein. All attempts to resolve the proteinExpand
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