C. Ashby

Publications268
h-index53
Citations10,737
Highly Influential Citations333
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Dopamine D3 Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats
TLDR
An important role for D3 receptors in mediating the addictive properties of cocaine is suggested and blockade of dopamine D3receptors may constitute a new and useful target for prospective pharmacotherapies for cocaine addiction.
Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain.
TLDR
It is speculated that because the experience of the high is associated with the fast uptake of cocaine and methylphenidate in the brain, the slow clearance ofethylphenidate from the brain may serve as a limiting factor in promoting its frequent self-administration.
The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade.
TLDR
The development of new compounds and the re-evaluation of compounds originally designed for other targets as transport inhibitors of ATP-dependent drug efflux pumps are summarized.
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance.
TLDR
It is concluded that erlotinib reverses ABCB 1- and ABCG2-mediated MDR in cancer cells through direct inhibition of the drug efflux function of ABCB1 andABCG2.
BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review.
TLDR
An overview about the current treatment of Ph+ CML patients with the TKIs and the obstacles to successful treatment with these drugs is presented.
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.
TLDR
Investigation of the ability of lapatinib to reverse tumor multidrug resistance (MDR) due to overexpression of ABC subfamily B member 1 (ABCB1) and ABCsubfamily G member 2 (ABCG2) transporters found it reverses ABCB1- and ABCG2-mediated MDR by directly inhibiting their transport function.
Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats
TLDR
The mesolimic DA D3 receptor plays an important role in mediating stress-induced reinstatement of cocaine-seeking behavior and is investigated in rats allowed to self-administer cocaine for 10–14 days.
The Novel Dopamine D3 Receptor Antagonist NGB 2904 Inhibits Cocaine's Rewarding Effects and Cocaine-Induced Reinstatement of Drug-Seeking Behavior in Rats
TLDR
The data show that the novel D3-selective antagonist NGB 2904 attenuates cocaine's rewarding effects as assessed by PR self-administration, BSR, and cocaine-triggered reinstatement of cocaine-seeking behavior.
Serotonergic modulation of striatal dopamine measured with positron emission tomography (PET) and in vivo microdialysis
TLDR
These data demonstrate that 5- HT-selective drugs produce changes in striatal dopamine that can be measured noninvasively with PET, and have implications for understanding the therapeutic efficacy of atypical neuroleptics and their utility for treating schizophrenia and affective disorders.
Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters.
TLDR
It is reported for the first time that nilotinib potentiates the cytotoxicity of widely used therapeutic substrates of ABCG2, such as mitoxantrone, doxorubicin, and ABCB1 substrates including colchicine, vincristine, and paclitaxel.
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