Dopamine D3 Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats
An important role for D3 receptors in mediating the addictive properties of cocaine is suggested and blockade of dopamine D3receptors may constitute a new and useful target for prospective pharmacotherapies for cocaine addiction.
The modulation of ABC transporter-mediated multidrug resistance in cancer: a review of the past decade.
Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain.
It is speculated that because the experience of the high is associated with the fast uptake of cocaine and methylphenidate in the brain, the slow clearance ofethylphenidate from the brain may serve as a limiting factor in promoting its frequent self-administration.
BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review.
Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.
Investigation of the ability of lapatinib to reverse tumor multidrug resistance (MDR) due to overexpression of ABC subfamily B member 1 (ABCB1) and ABCsubfamily G member 2 (ABCG2) transporters found it reverses ABCB1- and ABCG2-mediated MDR by directly inhibiting their transport function.
Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance.
It is concluded that erlotinib reverses ABCB 1- and ABCG2-mediated MDR in cancer cells through direct inhibition of the drug efflux function of ABCB1 andABCG2.
Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats
The mesolimic DA D3 receptor plays an important role in mediating stress-induced reinstatement of cocaine-seeking behavior and is investigated in rats allowed to self-administer cocaine for 10–14 days.
The Novel Dopamine D3 Receptor Antagonist NGB 2904 Inhibits Cocaine's Rewarding Effects and Cocaine-Induced Reinstatement of Drug-Seeking Behavior in Rats
The data show that the novel D3-selective antagonist NGB 2904 attenuates cocaine's rewarding effects as assessed by PR self-administration, BSR, and cocaine-triggered reinstatement of cocaine-seeking behavior.
Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters.
Selective dopamine D3 receptor antagonism by SB‐277011A attenuates cocaine reinforcement as assessed by progressive‐ratio and variable‐cost–variable‐payoff fixed‐ratio cocaine self‐administration in…
- Z. Xi, Jeremy G. Gilbert, Arlene C. Pak, C. Ashby, C. Heidbreder, E. Gardner
- Biology, PsychologyEuropean Journal of Neuroscience
- 1 June 2005
It is shown that SB‐277011A significantly inhibits acute cocaine‐induced reinforcement except at high cocaine doses and low work requirement for cocaine.