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Irreversible inhibition of glucose-6-phosphate dehydrogenase by the coenzyme A conjugate of ketoprofen: a key to oxidative stress induced by non-steroidal anti-inflammatory drugs?
TLDR
It is hypothesised that Glucose-6-phosphate dehydrogenase is the target of carboxylic NSAIDs, via their CoA metabolites, and KPF-CoA was effectively shown to bind covalently to the unique cysteine residue of the yeast enzyme. Expand
Adrenomedullin increases fibroblast-like synoviocyte adhesion to extracellular matrix proteins by upregulating integrin activation
TLDR
The results support a new role for adrenomedullin in rheumatoid synovial fibroblast pathobiology and exclude OA-FLS adhesion, which is normally found in patients with RA. Expand
Adrenomedullin, a neuropeptide with immunoregulatory properties induces semi‐mature tolerogenic dendritic cells
TLDR
It is demonstrated that AM and its receptors are expressed in DC and that exogenous AM can modify the DC phenotype and functions and can induce a semi‐mature DC phenotype with IDO expression, indicating close interactions among immune system regulation mechanisms and calcitonin‐like peptides. Expand
Distribution of adenosine 5'-triphosphate (ATP)-dependent hexose kinases in microorganisms.
TLDR
The pattern of distribution of ATP-dependent hexose kinases among microorganisms seems to parallel that reported for biosynthetic pathways for lysine. Expand
Interaction of the Electrophilic Ketoprofenyl-Glucuronide and Ketoprofenyl-Coenzyme A Conjugates with Cytosolic Glutathione S-Transferases
TLDR
It is concluded that KPF-SCoA is both a GST inhibitor and a substrate of a GST-dependent transacylation reaction, which may have potential implications on the reported in vivo toxicity of some carboxylic acid-containing drugs. Expand
Up‐regulation of fatty acid metabolizing‐enzymes mRNA in rat spinal cord during persistent peripheral local inflammation
TLDR
The findings suggest that the fatty metabolism is stimulated in the CNS during a chronic pain state, with the involvement of the neurotransmitter glutamate in the central ACS and ACO up‐regulation. Expand
Adrenomedullin(22-52) combats inflammation and prevents systemic bone loss in murine collagen-induced arthritis.
TLDR
The findings indicate that adrenomedullin(22-52) , which has no vasoactive or tumor-inducing effects, is a potent antiinflammatory and bone-protective agent in this arthritis model. Expand
Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families.
TLDR
Findings provided no significant linkage or association of adrenomedullin and CRLR-RAMP-2 genes with RA in the studied trio families. Expand