• Publications
  • Influence
Shifts in bacterial communities of two caribbean reef-building coral species affected by white plague disease
TLDR
Comparisons of the microbiome of healthy and WPD-affected corals from the two reef-building species Diploria strigosa and Siderastrea siderea collected at the Tayrona National Park suggest a loss of community-mediated growth control mechanisms on bacterial populations specific for each holobiont system.
Analysis of the quorum‐sensing regulon of the opportunistic pathogen Burkholderia cepacia H111 by proteomics
TLDR
Compared the protein pattern of the intracellular, extracellular, and surface protein fractions of an AHL‐deficient cepI mutant with the one of the parent strain H111 by means of two‐dimensional gel electrophoresis (2‐DE), it was shown that 55 proteins out of 985 detected spots were differentially expressed; these are expected to represent QS‐controlled gene products.
Cembranoid diterpenes from the Caribbean sea whip Eunicea knighti.
TLDR
Three new cembranoid diterpenes, knightol, knightal, and knightal were isolated as major compounds from the sea whip Eunicea knighti collected from the Colombian Caribbean and showed significant antimicrobial activity against bacterial isolates and excellent anti-QS inhibition activity measured by means of bioluminescence inhibition with biosensor model systems.
Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics.
TLDR
It is shown that the quorum-sensing blocker C-30 specifically interferes with the expression of 67% of the AHL-controlled protein spots of the surface fraction, confirming the high specificity of the compound.
Disruption in quorum-sensing systems and bacterial biofilm inhibition by cembranoid diterpenes isolated from the octocoral Eunicea knighti.
TLDR
Three new cembranoid diterpenes, knightine, knightal, and 11(R)-hydroxy-12(20)-en-knightal, were isolated as minor constituents of the Caribbean gorgonian Eunicea knighti and determined by detailed spectroscopic analyses and combination of chemical transformations and modified Mosher's methods.
A Proteomics View of Quorum-Sensing Regulated and Surface Induced Genes in Representative Pseudomonas and Burkholderia species
TLDR
Results indicate that QS represents a global regulatory system in B. cenocepacia, an important pathogen involved in cystic fibrosis, and the contribution of QS to the pathogenic competence of strains isolated from the sputa of two CF-patients was studied.
...
1
2
3
...