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Endiandric acid analogues from Beilschmiedia ferruginea as dual inhibitors of Bcl-xL/Bak and Mcl-1/Bid interactions.
A rapid screening by (1)H and (1)H-(13)C HSQC NMR spectroscopy of EtOAc extracts of Endiandra and Beilschmiedia species allowed the selection of Beilschmiedia ferruginea leaves and flowers extractExpand
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Cytotoxic sesquiterpenoids from Winteraceae of Caledonian rainforest.
One secobutanolide, two butanolides and six drimane sesquiterpenoids were isolated from the bark and leaves of Zygogynum pancheri and Zygogynum acsmithii (Winteraceae) along with six known drimanes,Expand
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Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks.
Natural products represent an inexhaustible source of novel therapeutic agents. Their complex and constrained three-dimensional structures endow these molecules with exceptional biologicalExpand
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Searching for original natural products by molecular networking: detection, isolation and total synthesis of chloroaustralasines
With the aim of isolating structurally original natural products, a molecular networking (MN)-based prioritisation approach has been developed and applied to a collection of 292 plant extracts. ItExpand
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Antiplasmodial, antitrypanosomal, and cytotoxic activities of prenylated flavonoids isolated from the stem bark of Artocarpus styracifolius.
In continuation of our efforts to find new antimalarial drugs, a systematic IN VITRO evaluation using a chloroquine resistant strain of PLASMODIUM FALCIPARUM (FcB1) was undertaken on extractsExpand
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Phenanthrene derivatives from Appendicula reflexa as new CDK1/cyclin B inhibitors
Abstract The chemical investigation of the epiphytic orchid Appendicula reflexa led to the isolation of one new phenanthrene, 3,4,6,7-tetramethoxyphenanthrene-2,8-diol (1) and one new bisphenanthreneExpand
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Natural Aristolactams and Aporphine Alkaloids as Inhibitors of CDK1/Cyclin B and DYRK1A
In an effort to find potent inhibitors of the protein kinases DYRK1A and CDK1/Cyclin B, a systematic in vitro evaluation of 2,500 plant extracts from New Caledonia and French Guyana was performed.Expand
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Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach.
From a set of 292 Euphorbiaceae extracts, the use of a molecular networking (MN)-based prioritization approach highlighted three clusters (MN1-3) depicting ions from the bark extract of CodiaeumExpand
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N-myristoyltransferases inhibitory activity of ellagitannins from Terminalia bentzoë (L.) L. f. subsp. bentzoë.
N-myristoylation (Myr) is an eukaryotic N-terminal co- or post-translational protein modification in which the enzyme N-myristoyltransferase (NMT) transfers a fatty acid (C14:0) to the N-terminalExpand
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