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Purification of a paracrine factor, P-Mod-S, produced by testicular peritubular cells that modulates Sertoli cell function.
A testicular paracrine factor, P-Mod-S, was purified from conditioned medium obtained from serum-free cultures of peritubular cells. Stimulation of testicular transferrin production by culturedExpand
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Antisense c-myc retroviral vector suppresses established human prostate cancer.
Prostate cancer eventually becomes androgen resistant, resumes growth, and kills the patient. Characterization of genetic events that lead to androgen refractory prostatic neoplasia has revealed theExpand
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Progressive nuclear translocation of somatostatin analogs.
UNLABELLED Optimal cancer radiotherapy using Auger electron emitters requires selective localization of radionuclides in close proximity to tumor DNA. METHODS Intracellular trafficking ofExpand
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Transforming growth factor beta as a clinical biomarker for prostate cancer.
OBJECTIVES Tumor biomarkers to detect prostate cancer earlier may reduce prostate cancer deaths. Transforming growth factor-beta1 and -beta2 (TGF-beta1 and -beta2) become overexpressed in prostateExpand
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Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (noni)
Abstractnoni, the juice of the fruit from the Morinda citrifolia plant, has been used for centuries as a medicinal agent. We tested the effects of noni juice in a three-dimensional fibrin clot matrixExpand
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The role of VEGF pathways in human physiologic and pathologic angiogenesis.
BACKGROUND In preclinical models, VEGF is a potent stimulant of both physiologic and pathologic angiogenesis. Conversely, anti-VEGF regimens have successfully inhibited angiogenesis both in vitro andExpand
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Cell‐Cell Interactions and the Regulation of Testis Function
Regulatory interactions have been shown to occur between all the testicular cell types considered. The paracrine factors mediating these interactions generally influence either cellular growth orExpand
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Immunohistochemical localization of TGFβ1, TGFβ2, and TGFβ3 in normal and malignant human prostate
Prostate cancer eventually becomes androgen‐independent, suggesting that growth factors such as TGFβ1–3 may potentially contribute to prostate neoplasia. The pattern and level of TGFβ1–3 proteinExpand
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Inhibition of human angiogenesis with heparin and hydrocortisone
Angiogenesis is a critical determinant of tumor growth and the development of metastases. Heparin, steroids, and heparin/steroid combinations have been used in a variety of in vitro models and inExpand
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Black raspberry extract and fractions contain angiogenesis inhibitors.
Targeted therapies, such as agents that inhibit angiogenesis, offer hope as complementary agents in cancer therapy. Angiogenesis-inhibiting agents have the potential for inhibiting tumor growth andExpand
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