TMEM41B is a novel regulator of autophagy and lipid mobilization
- F. Moretti, Phil Bergman, B. Nyfeler
- Biology, ChemistryEMBO Reports
- 20 August 2018
It is proposed that TMEM41B is a novel ER‐localized regulator of autophagosome biogenesis and lipid mobilization and Immunostaining and interaction proteomics data suggest that TM EM41B localizes to the endoplasmic reticulum (ER).
Tumor Targeting with Antibody-Functionalized, Radiolabeled Carbon Nanotubes
- M. McDevitt, D. Chattopadhyay, D. Scheinberg
- Biology, ChemistryJournal of Nuclear Medicine
- 1 July 2007
The ability to specifically target tumor with prototype-radiolabeled or fluorescent-labeled, antibody-appended CNT constructs was encouraging and suggested further investigation of CNT as a novel delivery platform.
Ectopeptidases in pathophysiology
- C. Antczak, Ingrid De Meester, Brigitte Bauvois
- BiologyBioessays
- 13 February 2001
Combined analyses of gene organization and regulation of ectopeptidases by various physiological factors have provided insights into their structure–function relationships and may have implications in considering them as therapeutic targets.
Combining integrated genomics and functional genomics to dissect the biology of a cancer‐associated, aberrant transcription factor, the ASPSCR1–TFE3 fusion oncoprotein
- R. Kobos, M. Nagai, M. Ladanyi
- BiologyJournal of Pathology
- 1 April 2013
A combined integrated genomics/functional genomics strategy to dissect the biology of oncogenic, chimeric transcription factors is established and suggests new therapeutic possibilities for cancers driven by TFE3 fusions.
A new human peptide deformylase inhibitable by actinonin.
- Mona D Lee, C. Antczak, Yueming Li, F. Sirotnak, W. Bornmann, D. Scheinberg
- BiologyBiochemical and Biophysical Research…
- 12 December 2003
Live-Cell Imaging of Caspase Activation for High-Content Screening
- C. Antczak, T. Takagi, Christina N. Ramirez, C. Radu, Hakim Djaballah
- BiologyJournal of biomolecular screening
- 1 September 2009
The results demonstrate the feasibility of using this newly adapted and validated high-content assay to screen chemical or RNAi libraries for the identification of previously uncovered enhancers and suppressors of the apoptotic machinery in live cells.
Domain-based biosensor assay to screen for epidermal growth factor receptor modulators in live cells.
- C. Antczak, A. Bermingham, Hakim Djaballah
- BiologyAssay and drug development technologies
- 21 February 2012
A novel strategy utilizing a green fluorescent protein-labeled SRC homology 2 domain-based biosensor as a surrogate reporter of endogenous epidermal growth factor receptor (EGFR) activity in A549 cells is adapted, allowing for the identification of novel EGFR modulators in high-throughput formats for screening chemical and RNAi libraries.
ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells
- B. Wee, A. Pietras, E. Holland
- BiologyScientific Reports
- 26 July 2016
It is shown that ABCG2 can actively drive expression of stem cell markers and self-renewal in glioma cells, and this data demonstrate that characteristics of tumor stem cells are separable, and highlightABCG2 as a potential driver ofglioma stemness.
A class of allosteric caspase inhibitors identified by high-throughput screening.
- Taya Feldman, V. Kabaleeswaran, Xuejun Jiang
- Biology, ChemistryMolecules and Cells
- 24 August 2012
A high-content assay strategy for the identification and profiling of ABCG2 modulators in live cells.
- C. Antczak, B. Wee, C. Radu, B. Bhinder, E. Holland, Hakim Djaballah
- BiologyAssay and drug development technologies
- 18 February 2014
The results demonstrate that the live cell and content-rich platform enables the rapid identification and profiling of ABCG2 modulators, and this new strategy opens the door to the discovery of compounds targeting the expression and/or trafficking of ABC transporters as an alternative to functional inhibitors that failed in the clinic.
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