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Experimental chemotherapy with Allium sativum (Liliaceae) methanolic extract in rodents infected with Leishmania major and Leishmania donovani.
TLDR
Since the mechanism of action for the methanolic extract is apparently immunomodulatory, garlic compounds could be purified and tried as complementary medicine in the management of leishmaniases. Expand
The chemotactic effect of Phlebotomus duboscqi (Diptera: Psychodidae) salivary gland lysates to murine monocytes.
TLDR
In vitro studies showed that salivary gland lysates of P. duboscqi, the vector of Leishmania major in Kenya, are chemotactic to mouse peritoneal monocytes, which may form part of the mechanisms through which sandfly saliva ensures successful parasitization of macrophages in a susceptible host by Leishmaniasis parasites. Expand
The phlebotomine sandfly fauna (Diptera: Psychodidae) of Kenya.
TLDR
This review is a compilation of the currently known distribution of phlebotomine sandflies in the parts of Kenya that have been studied, from the time sandflies were first reported in the country. Expand
Development of Leishmania major in Phlebotomus duboscqi and Sergentomyia schwetzi (Diptera: Psychodidae).
TLDR
The extrinsic development of Leishmania major was observed in 2 man-biting sand flies, Phlebotomus duboscqi, a known vector, and Sergentomyia schwetzi, an assumed non-vector, which indicates that S. schWetzi is not a vector of L. major. Expand
Vervet Monkeys Vaccinated with Killed Leishmania major Parasites and Interleukin-12 Develop a Type 1 Immune Response but Are Not Protected against Challenge Infection
TLDR
Data suggest that protection against leishmaniasis may require more than the activation of Leishmania-specific IFN-γ-producing T cells, which has important implications for designing a vaccine against leishingmaniasis. Expand
Phlebotomus guggisbergi (Diptera: Psychodidae), a vector of Leishmania tropica in Kenya.
TLDR
The finding of such a large number of P. guggisbergi naturally harboring mature infections of L. tropica at an active case site of cutaneous leishmaniasis due to this agent strongly implicates this fly as a vector. Expand
Isolation of Leishmania donovani from Phlebotomus martini in Baringo district, Kenya.
TLDR
An 18-month sandfly survey was conducted at 4 locations in Baringo District, Rift Valley Province, Kenya and the finding of 2 P. martini naturally infected with L. donovani strongly supports the hypothesis that this species is a vector of visceral leishmaniasis in this area. Expand
Laboratory and semi-field evaluation of long-lasting insecticidal nets against leishmaniasis vector, Phlebotomus (Phlebotomus) duboscqi in Kenya.
TLDR
Olyset net use in areas where sandflies are nuisance biters and/or disease vectors could be more beneficial in preventing sandfly bites than other tested bednets. Expand
Phlebotomus (Larroussius) orientalis (Diptera: Psychodidae) as a probable secondary vector of visceral leishmaniasis in Kenya.
TLDR
The study investigated Phlebotomus orientalis possible role in the transmission of kalaazar in an endemic area where P. martini, the known vector of the disease in other parts of Kenya was seemingly absent but transmission has been going on. Expand
Leishmania major: the suitability of East African nonhuman primates as animal models for cutaneous leishmaniasis.
TLDR
This study shows that the vervets, Syke's, and the baboons are equally susceptible to L. major infection, while bushbabies are refractory and are considered as suitable models for drug or vaccine trials against human zoonotic cutaneous leishmaniasis. Expand
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