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A Systematic Review and Meta-Analysis of Endocrine-Related Adverse Events Associated with Immune Checkpoint Inhibitors.
TLDR
A meta-analysis shows a high incidence of endocrine adverse events provoked by single agent checkpoint blockade, further reinforced by combined treatment, and combination therapy was associated with ahigh incidence of hypothyroidism. Expand
Estradiol Improves Cerebellar Memory Formation by Activating Estrogen Receptor β
TLDR
Estradiol can improve motor skills by potentiating cerebellar plasticity and synapse formation and may be advantageous during periods of high estradiol levels of the estrous cycle or pregnancy. Expand
Otolith deprivation induces optokinetic compensation.
TLDR
The data and the model support the presence of the multisensory integration system and reveal a compensatory enhanced optokinetic reflex in tilted mice, indicating an adaptive synergism in the processing of otolith and visually driven signals. Expand
A BEHAVIORAL AND HISTOLOGICAL STUDY OF THE EFFECTS OF LONG-TERM EXPOSURE OF ADULT RATS TO ALUMINUM
TLDR
Adult rats were intraperitoneally injected three times a week for 6 months with ecological doses of Al gluconate, and the Al overload was confirmed by the significantly increased level of Al in serum. Expand
Endocochlear potential depends on Cl− channels: mechanism underlying deafness in Bartter syndrome IV
TLDR
Bsnd−/− mice demonstrate a novel function of Cl− channels in generating the endocochlear potential and reveal the mechanism leading to deafness in human Bartter syndrome IV. Expand
NR2A subunit of the N-methyl d-aspartate receptors are required for potentiation at the mossy fiber to granule cell synapse and vestibulo-cerebellar motor learning
TLDR
Results indicate that NMDA-NR2A mediated potentiation at the mossy fiber to granule cell synapse is not required for basic motor performance, and they raise the possibility that it may contribute to some forms of vestibulo-cerebellar memory formation. Expand
Immune checkpoint inhibitor therapy for ACTH-secreting pituitary carcinoma: a new emerging treatment?
TLDR
Immune checkpoint inhibitors (ICI) therapy could be a promising treatment option for pituitary carcinoma, considering the mechanisms of TMZ-induced hypermutation with increased immunogenicity, pituitsary expression of CTLA-4 and PD-L1, and the frequent occurrence of hypophysitis as a side effect of ICI therapy. Expand
Adrenal Cushing's syndrome during pregnancy.
TLDR
Considering the cortisol responses to LHRH and hCG, and the development of CS during pregnancy in these patients, it is likely that ACTH-independent hypercortisolism was induced by the pregnancy-associated rise in hCG levels that activated aberrantly expressed LH receptors in the adrenal adenoma. Expand
A focused 35-minute whole body MRI screening protocol for patients with von Hippel-Lindau disease
TLDR
Annual screening in VHL disease can be done in a rapid, safe and sensitive way by using a dedicated whole body MRI protocol; saving MRI examination time and limiting Gadolinium dose. Expand
Postpartum microangiopathic disorders: A case report and review of the literature
TLDR
Treatment for TTP should be strongly considered in case of an on-going TMA more than 72 h after delivery, and treatment with plasma filtration, fresh frozen plasma and prednisolone resulted in a quick clinical and laboratory response. Expand
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