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The origin of extracellular fields and currents — EEG, ECoG, LFP and spikes
Neuronal activity in the brain gives rise to transmembrane currents that can be measured in the extracellular medium. Although the major contributor of the extracellular signal is the synapticExpand
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Theta Phase Segregation of Input-Specific Gamma Patterns in Entorhinal-Hippocampal Networks
Precisely how rhythms support neuronal communication remains obscure. We investigated interregional coordination of gamma oscillations using high-density electrophysiological recordings in the ratExpand
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Ephaptic coupling of cortical neurons
The electrochemical processes that underlie neural function manifest themselves in ceaseless spatiotemporal field fluctuations. However, extracellular fields feed back onto the electric potentialExpand
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Transcranial Electric Stimulation Entrains Cortical Neuronal Populations in Rats
Low intensity electric fields have been suggested to affect the ongoing neuronal activity in vitro and in human studies. However, the physiological mechanism of how weak electrical fields affect andExpand
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Fully integrated silicon probes for high-density recording of neural activity
TLDR
We design, fabricate and test a new silicon probe known as Neuropixels to meet this need. Expand
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A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents
Brain activity generates extracellular voltage fluctuations recorded as local field potentials (LFPs). It is known that the relevant microvariables, the ionic currents across membranes, jointlyExpand
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The Spiking Component of Oscillatory Extracellular Potentials in the Rat Hippocampus
When monitoring neural activity using intracranial electrical recordings, researchers typically consider the signals to have two primary components: fast action potentials (APs) from neurons near theExpand
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Real-time spike sorting platform for high-density extracellular probes with ground-truth validation and drift correction
TLDR
We built a spike-sorting pipeline that performs reliably under noise and probe drift by incorporating covariance-based features and unsupervised clustering based on fast density-peak finding. Expand
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The Effect of Spatially Inhomogeneous Extracellular Electric Fields on Neurons
The cooperative action of neurons and glia generates electrical fields, but their effect on individual neurons via ephaptic interactions is mostly unknown. Here, we analyze the impact of spatiallyExpand
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Classification of electrophysiological and morphological neuron types in the mouse visual cortex
Understanding the diversity of cell types in the brain has been an enduring challenge and requires detailed characterization of individual neurons in multiple dimensions. To systematically profileExpand
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