• Publications
  • Influence
A 90-Day Continuous Vapor Inhalation Toxicity Study of JP-8 Jet Fuel Followed by 20 or 21 Months of Recovery in Fischer 344 Rats and C57BL/6 Mice
The kerosene-type jet fuel, JP-8, consists of a complex mixture of aliphatic and aromatic hydrocarbons. Because of the utility of JP-8, studies have been conducted to identify the potential long-termExpand
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Preparing for the twenty-first century.
  • C. Alden
  • Medicine
  • Toxicologic pathology
  • 1996
The pivotal technology for hazard identification following repeated exposure to xenobiotics continues to be pathology-specifically histopathology. Toxicologic pathologists are solidly positioned asExpand
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Interspecies Differences in Renal Localization of Cyclooxygenase Isoforms: Implications in Nonsteroidal Antiinflammatory Drug-Related Nephrotoxicity
Cyclooxygenase (COX) exists in 2 related but unique isoforms: one is constitutive (COX-1) and functions in normal cell physiology, and the other is inducible (COX-2) and is expressed in response toExpand
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The Tg rasH2 Mouse in Cancer Hazard Identification
The Tg rasH2 transgenic mouse has been developed as an alternative to the lifetime mouse bioassay to predict the carcinogenic potential of chemicals. Unlike the p53+/- mouse, the Tg rasH2 mouse isExpand
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A Review of Unique Male Rat Hydrocarbon Nephropathy
  • C. Alden
  • Biology, Medicine
  • Toxicologic pathology
  • 1 January 1986
There is a diverse group of hydrocarbons that induce a specific spectrum of nephropathic alterations. Examples include decalin, an alicyclic hydrocarbon; JP5 jet fuel, a mixture of C12–13 straightExpand
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A Critical Review of the Effectiveness of Rodent Pharmaceutical Carcinogenesis Testing in Predicting for Human Risk
The pharmaceutical industry and regulatory agency toxicology testing paradigms in the United States currently appear successful, in part because of the continuously increasing life expectancy and theExpand
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Differential Display in Rat Livers Treated for 13 Weeks with Phenobarbital Implicates a Role for Metabolic and Oxidative Stress in Nongenotoxic Carcinogenicity
Hepatic enzyme inducers such as phenobarbital are often nongenotoxic rodent hepatocarcinogens. Currently, nongenotoxic hepatocarcinogens can only be definitively identified through costly andExpand
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An Analysis of Pharmaceutical Experience with Decades of Rat Carcinogenicity Testing
Data collected from 182 marketed and nonmarketed pharmaceuticals demonstrate that there is little value gained in conducting a rat two-year carcinogenicity study for compounds that lack: (1)Expand
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Acute molecular markers of rodent hepatic carcinogenesis identified by transcription profiling.
Currently, the only way to identify nongenotoxic hepatocarcinogens is through long-term repeat dose studies such as the 2 year rodent carcinogenicity assay. Such assays are both time consuming andExpand
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Xpa and Xpa/p53+/- Knockout Mice: Overview of Available Data
DNA repair defi cient Xpa-/- and Xpa-/- /p53 +/- knock-out mice in a C57BL/6 genetic background, referred to as respectively the XPA and XPA/p53 model, were investigatedinthe internationalExpand
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