Blood velocity and pressure fields in large arteries are greatly influenced by the deformability of the vessel. Moreover, wave propagation phenomena in the cardiovascular system can only be described… (More)
Flow and pressure waves emanate from the heart and travel through the major arteries where they are damped, dispersed and reflected due to changes in vessel caliber, tissue properties and branch… (More)
Coronary flow is different from the flow in other parts of the arterial system because it is influenced by the contraction and relaxation of the heart. To model coronary flow realistically, the… (More)
This 10-day, single-center, open-label, randomized, crossover study compared pharmacokinetic profiles and tolerability of extended release quetiapine fumarate (quetiapine XR) with quetiapine… (More)
It is now well known that altered hemodynamics can alter the genes that are expressed by diverse vascular cells, which in turn plays a critical role in the ability of a blood vessel to adapt to new… (More)
Advances in numerical methods and three-dimensional imaging techniques have enabled the quantification of cardiovascular mechanics in subject-specific anatomic and physiologic models.… (More)
Abdominal aortic aneurysms (AAAs) affect 5–7% of older Americans. We hypothesize that exercise may slow AAA growth by decreasing inflammatory burden, peripheral resistance, and adverse hemodynamic… (More)
BACKGROUND
Atherosclerotic plaque in the descending thoracic aorta (dAo) is related to altered wall shear stress (WSS) for normal patients. Resection with end-to-end anastomosis (RWEA) is the gold… (More)
PURPOSE
To assess 3-dimensional (3D) pulsatile displacement forces (DF) acting on thoracic endografts using 3D computational techniques.
METHODS
A novel computational method to quantitate the… (More)
Aortic flow and pressure result from the interactions between the heart and arterial system. In this work, we considered these interactions by utilizing a lumped parameter heart model as an inflow… (More)