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Genetic variants of IL-13 signalling and human asthma and atopy.
Asthma and atopy show epidemiological association and are biologically linked by T-helper type 2 (T(h)2) cytokine-driven inflammatory mechanisms. IL-4 operates through the IL-4 receptor (IL-4R, a… Expand
Immunomodulation by Mesenchymal Stem Cells A Potential Therapeutic Strategy for Type 1 Diabetes
Mesenchymal stem cells (MSCs) are pluripotent stromal cells that have the potential to give rise to cells of diverse lineages. Interestingly, MSCs can be found in virtually all postnatal tissues. The… Expand
The mouse Pgk-1 gene promoter contains an upstream activator sequence.
- M. McBurney, L. Sutherland, C. Adra, B. Leclair, M. Rudnicki, K. Jardine
- Biology, Medicine
- Nucleic acids research
- 25 October 1991
The Pgk-1 gene encodes the housekeeping enzyme, 3-phosphoglycerate kinase, and is ubiquitously expressed. This gene resides on the X chromosome in mammals and is always expressed except where it is… Expand
Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter.
We report the cloning of the mouse pgk-1 gene encoding the somatic cell isoform of the enzyme phosphoglycerate kinase. The gene is contained within a 16-kb region of the X chromosome and is… Expand
Immunomodulatory Function of Bone Marrow-Derived Mesenchymal Stem Cells in Experimental Autoimmune Type 1 Diabetes1
Human clinical trials in type 1 diabetes (T1D) patients using mesenchymal stem cells (MSC) are presently underway without prior validation in a mouse model for the disease. In response to this void,… Expand
A TRPV2–PKA Signaling Module for Transduction of Physical Stimuli in Mast Cells
- Alexander J Stokes, L. Shimoda, M. Koblan-Huberson, C. Adra, H. Turner
- Biology, Medicine
- The Journal of experimental medicine
- 19 July 2004
Cutaneous mast cell responses to physical (thermal, mechanical, or osmotic) stimuli underlie the pathology of physical urticarias. In vitro experiments suggest that mast cells respond directly to… Expand
LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells.
While a large body of knowledge about cell membrane proteins exists, much less is known about the repertoire and function of integral membrane proteins of intracellular organelles. In looking for… Expand
Fluorescence in situ hybridization mapping of translocations and deletions involving the short arm of human chromosome 12 in malignant hematologic diseases.
Translocations and deletions of the short arm of chromosome 12 [t(12p) and del(12p)] are common recurring abnormalities in a broad spectrum of hematologic malignant diseases. We studied 20 patients… Expand
Fascin Is a Key Regulator of Breast Cancer Invasion That Acts via the Modification of Metastasis-Associated Molecules
The actin-bundling protein, fascin, is a member of the cytoskeletal protein family that has restricted expression in specialized normal cells. However, many studies have reported the induction of… Expand
The testis-specific phosphoglycerate kinase gene pgk-2 is a recruited retroposon.
- P. Boer, C. Adra, Y. Lau, M. McBurney
- Medicine, Biology
- Molecular and cellular biology
- 1 September 1987
In both humans and mice, two genes encode phosphoglycerate kinase, a key enzyme in the glycolytic pathway. The pgk-1 gene is expressed in all somatic cells, is located on the X chromosome, and… Expand