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Reduced airway inflammation in CD26/DPP4‐deficient F344 rats is associated with altered recruitment patterns of regulatory T cells and expression of pulmonary surfactant proteins
Introduction CD26 is highly expressed on lung epithelial cells as well as on immune cells. Ovalbumin (OVA)‐induced airway inflammation induces a further increase of CD26 expression. CD26‐deficientExpand
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Developmental changes in rat surfactant lipidomics in the context of species variability
Lung surfactant comprises mainly phosphatidylcholine (PC) species together with phosphatidylglycerols and surfactant proteins (SP) SP‐A to ‐D. Changes in the concentrations of its principalExpand
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Active surfactant in pharyngeal aspirates of term neonates: lipid biochemistry and surface tension function
Alveolar surfactant is well known for its ability to reduce minimal surface tension at the alveolar air–liquid interface to values below 5 mN m−1. In addition, it has been suggested that surfactantExpand
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Surfactant alterations following donation after cardiac death donor lungs
The use of lungs from donation after cardiac death (DCD) donors is one of the strategies to increase the donor pool. The aim of this study was to assess the surfactant alterations in DCD donor lungs.Expand
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Molecular and functional changes of pulmonary surfactant in response to hyperoxia
Surfactant comprises phosphatidylcholine (PC) together with anionic phospholipids, neutral lipids, and surfactant proteins SP‐A to‐D. Its composition is highly specific, with dipalmitoyl‐PC,Expand
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Characterization of surfactant alterations in pigs infected with Actinobacillus pleuropneumoniae
ABSTRACT Purpose/Aim of the study: Surfactant, a surface active complex of phospholipids and proteins located at the inner surface of alveoli and small conducting airways is necessary for breathing.Expand
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Stereological and biophysical characteristics of the ovine surfactant system and its changes caused by ovine pulmonary adenocarcinoma.
Surfactant covers the inner surface of lung alveoli and lowers the surface tension to prevent alveoli from collapsing. A lack of surfactant or its dysfunction causes dyspnea. The Jaagsiekte SheepExpand
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355 ABNORMALLY HIGH SURFACE TENSION OF LUNG SURFACTANT IN 2 INFANTS WITH SEVERE APPARENT LIFE-THREATENING EVENTS (ALTE)
There is evidence to suggest that small airway closure may be involved in ALTE1. We present data from 2 infants who showed an abnormally high surface tension of their pulmonary surfactant. The firstExpand
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290 SURFACE ADSORPTION AND MINIMAL SURFACE TENSION OF BRONCHIAL SURFACTANT PREPARATIONS WITH AND WITHOUT EXOGENOUS SURFACTANT IN PULMONARY DISEASES
Few publications have described the activity of surfactant harvested from tracheo-bronchial material of patients with pulmonary diseases using a bubble-surfactometer. We first determined the minimalExpand
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